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ApoE facilitates the microglial response to amyloid plaque pathology

Overview of attention for article published in The Journal of Experimental Medicine, February 2018
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (87th percentile)
  • Average Attention Score compared to outputs of the same age and source

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27 X users
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Title
ApoE facilitates the microglial response to amyloid plaque pathology
Published in
The Journal of Experimental Medicine, February 2018
DOI 10.1084/jem.20171265
Pubmed ID
Authors

Jason D. Ulrich, Tyler K. Ulland, Thomas E. Mahan, Sofie Nyström, K. Peter Nilsson, Wilbur M. Song, Yingyue Zhou, Mariska Reinartz, Seulah Choi, Hong Jiang, Floy R. Stewart, Elise Anderson, Yaming Wang, Marco Colonna, David M. Holtzman

Abstract

One of the hallmarks of Alzheimer's disease is the presence of extracellular diffuse and fibrillar plaques predominantly consisting of the amyloid-β (Aβ) peptide. Apolipoprotein E (ApoE) influences the deposition of amyloid pathology through affecting the clearance and aggregation of monomeric Aβ in the brain. In addition to influencing Aβ metabolism, increasing evidence suggests that apoE influences microglial function in neurodegenerative diseases. Here, we characterize the impact that apoE has on amyloid pathology and the innate immune response in APPPS1ΔE9 and APPPS1-21 transgenic mice. We report thatApoedeficiency reduced fibrillar plaque deposition, consistent with previous studies. However, fibrillar plaques inApoe-deficient mice exhibited a striking reduction in plaque compaction. Hyperspectral fluorescent imaging using luminescent conjugated oligothiophenes identified distinct Aβ morphotypes inApoe-deficient mice. We also observed a significant reduction in fibrillar plaque-associated microgliosis and activated microglial gene expression inApoe-deficient mice, along with significant increases in dystrophic neurites around fibrillar plaques. Our results suggest that apoE is critical in stimulating the innate immune response to amyloid pathology.

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X Demographics

The data shown below were collected from the profiles of 27 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 307 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 307 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 63 21%
Researcher 57 19%
Student > Bachelor 33 11%
Student > Master 28 9%
Student > Doctoral Student 12 4%
Other 39 13%
Unknown 75 24%
Readers by discipline Count As %
Neuroscience 86 28%
Biochemistry, Genetics and Molecular Biology 33 11%
Agricultural and Biological Sciences 23 7%
Medicine and Dentistry 21 7%
Immunology and Microbiology 17 6%
Other 32 10%
Unknown 95 31%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 18. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 August 2023.
All research outputs
#2,086,779
of 25,382,440 outputs
Outputs from The Journal of Experimental Medicine
#1,318
of 11,599 outputs
Outputs of similar age
#43,904
of 343,860 outputs
Outputs of similar age from The Journal of Experimental Medicine
#32
of 63 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 11,599 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.4. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 343,860 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 63 others from the same source and published within six weeks on either side of this one. This one is in the 49th percentile – i.e., 49% of its contemporaries scored the same or lower than it.