| Title |
Chemistry, physiological properties, and microbial production of hydroxycitric acid
|
|---|---|
| Published in |
Applied Microbiology and Biotechnology, May 2007
|
| DOI | 10.1007/s00253-007-0962-4 |
| Pubmed ID | |
| Authors |
Takashi Yamada, Hiroyuki Hida, Yasuhiro Yamada |
| Abstract |
The tropical plants Garcinia cambogia and Hibiscus subdariffa produce hydroxycitric acid (HCA), of which the absolute configurations are (2S,3S) and (2S,3R), respectively. (2S,3S)-HCA is an inhibitor of ATP-citrate lyase, which is involved in fatty acid synthesis. (2S,3R)-HCA inhibits pancreatic alpha-amylase and intestinal alpha-glucosidase, leading to a reduction in carbohydrate metabolism. In this study, we review current knowledge on the structure, biological occurrence, and physiological properties of HCA. The availability of HCA is limited by the restricted habitat of its source plants and the difficulty of stereoselective organic synthesis. Hence, in our recent study, thousands of microbial strains were screened and finally two bacterial strains were, for the first time, found to produce trace amounts of HCA. The HCA variants produced were the Hibiscus-type (2S,3R) enantiomer. Subsequent genome shuffling rapidly generated a mutant population with improved HCA yield relative to the parent strain of bacteria. These bacteria are a potential alternative source of natural HCA. |
Mendeley readers
The data shown below were compiled from readership statistics for 96 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Malaysia | 1 | 1% |
| Indonesia | 1 | 1% |
| Australia | 1 | 1% |
| Brazil | 1 | 1% |
| Sweden | 1 | 1% |
| United States | 1 | 1% |
| Unknown | 90 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 18 | 19% |
| Researcher | 13 | 14% |
| Student > Master | 12 | 13% |
| Student > Bachelor | 9 | 9% |
| Student > Postgraduate | 6 | 6% |
| Other | 15 | 16% |
| Unknown | 23 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 22 | 23% |
| Chemistry | 11 | 11% |
| Medicine and Dentistry | 9 | 9% |
| Biochemistry, Genetics and Molecular Biology | 9 | 9% |
| Chemical Engineering | 5 | 5% |
| Other | 14 | 15% |
| Unknown | 26 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 July 2018.
All research outputs
#2,476,827
of 24,119,703 outputs
Outputs from Applied Microbiology and Biotechnology
#223
of 8,034 outputs
Outputs of similar age
#5,410
of 74,284 outputs
Outputs of similar age from Applied Microbiology and Biotechnology
#5
of 74 outputs
Altmetric has tracked 24,119,703 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 8,034 research outputs from this source. They receive a mean Attention Score of 4.3. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 74,284 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 74 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.