Title |
Kynurenines in chronic neurodegenerative disorders: future therapeutic strategies
|
---|---|
Published in |
Journal of Neural Transmission, July 2009
|
DOI | 10.1007/s00702-009-0263-4 |
Pubmed ID | |
Authors |
D. Zádori, P. Klivényi, E. Vámos, F. Fülöp, J. Toldi, L. Vécsei |
Abstract |
Parkinson's, Alzheimer's and Huntington's diseases are chronic neurodegenerative disorders of a progressive nature which lead to a considerable deterioration of the quality of life. Their pathomechanisms display some common features, including an imbalance of the tryptophan metabolism. Alterations in the concentrations of neuroactive kynurenines can be accompanied by devastating excitotoxic injuries and metabolic disturbances. From therapeutic considerations, possibilities that come into account include increasing the neuroprotective effect of kynurenic acid, or decreasing the levels of neurotoxic 3-hydroxy-L-kynurenine and quinolinic acid. The experimental data indicate that neuroprotection can be achieved by both alternatives, suggesting opportunities for further drug development in this field. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Poland | 1 | 2% |
Unknown | 43 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 9 | 20% |
Student > Ph. D. Student | 8 | 18% |
Student > Master | 8 | 18% |
Student > Bachelor | 4 | 9% |
Professor | 3 | 7% |
Other | 6 | 14% |
Unknown | 6 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 11 | 25% |
Agricultural and Biological Sciences | 8 | 18% |
Biochemistry, Genetics and Molecular Biology | 6 | 14% |
Medicine and Dentistry | 3 | 7% |
Engineering | 2 | 5% |
Other | 6 | 14% |
Unknown | 8 | 18% |