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Molecular cloning of a cDNA encoding interleukin 11, a stromal cell-derived lymphopoietic and hematopoietic cytokine.

Overview of attention for article published in Proceedings of the National Academy of Sciences of the United States of America, October 1990
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (95th percentile)
  • High Attention Score compared to outputs of the same age and source (89th percentile)

Mentioned by

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34 patents
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2 Wikipedia pages

Citations

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597 Dimensions

Readers on

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45 Mendeley
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1 Connotea
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Title
Molecular cloning of a cDNA encoding interleukin 11, a stromal cell-derived lymphopoietic and hematopoietic cytokine.
Published in
Proceedings of the National Academy of Sciences of the United States of America, October 1990
DOI 10.1073/pnas.87.19.7512
Pubmed ID
Authors

S R Paul, F Bennett, J A Calvetti, K Kelleher, C R Wood, R M O'Hara, A C Leary, B Sibley, S C Clark, D A Williams

Abstract

Hematopoiesis occurs in close association with a complex network of cells loosely termed the hematopoietic microenvironment. Analysis of the mechanisms of microenvironmental regulation of hematopoiesis has been hindered by the complexity of the microenvironment as well as the heterogeneity of hematopoietic stem cells and early progenitor cells. We have established immortalized primate bone marrow-derived stromal cell lines to facilitate analysis of the interactions of hematopoietic cells with the microenvironment in a large animal species. One such line, PU-34, was found to produce a variety of growth factors, including an activity that stimulates the proliferation of an interleukin 6-dependent murine plasmacytoma cell line. A cDNA encoding the plasmacytoma stimulatory activity was isolated through functional expression cloning in mammalian cells. The nucleotide sequence contained a single long reading frame of 597 nucleotides encoding a predicted 199-amino acid polypeptide. The amino acid sequence of this cytokine, designated interleukin 11 (IL-11), did not display significant similarity with any other sequence in the GenBank data base. Preliminary biological characterization indicates that in addition to stimulating plasmacytoma proliferation, IL-11 stimulates the T-cell-dependent development of immunoglobulin-producing B cells and synergizes with IL-3 in supporting murine megakaryocyte colony formation. These properties implicate IL-11 as an additional multifunctional regulator in the hematopoietic microenvironment.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 1 2%
Germany 1 2%
Australia 1 2%
Unknown 42 93%

Demographic breakdown

Readers by professional status Count As %
Student > Doctoral Student 8 18%
Student > Master 7 16%
Student > Bachelor 6 13%
Researcher 6 13%
Student > Ph. D. Student 4 9%
Other 5 11%
Unknown 9 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 12 27%
Biochemistry, Genetics and Molecular Biology 10 22%
Medicine and Dentistry 8 18%
Immunology and Microbiology 3 7%
Nursing and Health Professions 1 2%
Other 1 2%
Unknown 10 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 September 2022.
All research outputs
#2,744,162
of 24,625,114 outputs
Outputs from Proceedings of the National Academy of Sciences of the United States of America
#30,328
of 101,438 outputs
Outputs of similar age
#580
of 16,383 outputs
Outputs of similar age from Proceedings of the National Academy of Sciences of the United States of America
#20
of 296 outputs
Altmetric has tracked 24,625,114 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 101,438 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 38.8. This one has gotten more attention than average, scoring higher than 68% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 16,383 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 296 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.