| Title |
Mode of action of the antimicrobial compound 5-Bromo-5-nitro-1,3-dioxane (Bronidox)
|
|---|---|
| Published in |
Folia Microbiologica, February 1986
|
| DOI | 10.1007/bf02928676 |
| Pubmed ID | |
| Authors |
M. Ghannoum, M. Thomson, W. Bowman, S. Al-Khalil |
| Abstract |
The mode of action of the antimicrobial agent, 5-bromo-5-nitro-1,3-dioxane (bronidox), was studied in detail for gram-positive and gram-negative bacteria, yeast and fungi. The studies included MIC testing, thiol inhibition of activity, intracellular leakage, oxygen consumption, incorporation of 3H-uridine, scanning electron microscopy, inhibition of enzyme activity (papain) and in vitro oxidation of thiols to disulfides. It appears that the primary mode of action of bronidox is the same as, or similar to, that of bronopol, i.e. the oxidation of essential protein thiol causing inhibition of enzyme activity and subsequent inhibition of microbial growth. |
Mendeley readers
The data shown below were compiled from readership statistics for 13 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 13 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 5 | 38% |
| Student > Bachelor | 2 | 15% |
| Researcher | 2 | 15% |
| Lecturer | 1 | 8% |
| Professor > Associate Professor | 1 | 8% |
| Other | 0 | 0% |
| Unknown | 2 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 4 | 31% |
| Chemistry | 2 | 15% |
| Immunology and Microbiology | 2 | 15% |
| Biochemistry, Genetics and Molecular Biology | 1 | 8% |
| Chemical Engineering | 1 | 8% |
| Other | 1 | 8% |
| Unknown | 2 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 October 2022.
All research outputs
#4,872,869
of 23,452,723 outputs
Outputs from Folia Microbiologica
#49
of 753 outputs
Outputs of similar age
#2,846
of 42,434 outputs
Outputs of similar age from Folia Microbiologica
#1
of 1 outputs
Altmetric has tracked 23,452,723 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 753 research outputs from this source. They receive a mean Attention Score of 2.9. This one has done well, scoring higher than 87% of its peers.
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We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them