| Title |
A Review of Microbiota and Irritable Bowel Syndrome: Future in Therapies
|
|---|---|
| Published in |
Advances in Therapy, March 2018
|
| DOI | 10.1007/s12325-018-0673-5 |
| Pubmed ID | |
| Authors |
Bruno K. Rodiño-Janeiro, María Vicario, Carmen Alonso-Cotoner, Roberto Pascua-García, Javier Santos |
| Abstract |
Irritable bowel syndrome (IBS), one of the most frequent digestive disorders, is characterized by chronic and recurrent abdominal pain and altered bowel habit. The origin seems to be multifactorial and is still not well defined for the different subtypes. Genetic, epigenetic and sex-related modifications of the functioning of the nervous and immune-endocrine supersystems and regulation of brain-gut physiology and bile acid production and absorption are certainly involved. Acquired predisposition may act in conjunction with infectious, toxic, dietary and life event-related factors to enhance epithelial permeability and elicit mucosal microinflammation, immune activation and dysbiosis. Notably, strong evidence supports the role of bacterial, viral and parasitic infections in triggering IBS, and targeting microbiota seems promising in view of the positive response to microbiota-related therapies in some patients. However, the lack of highly predictive diagnostic biomarkers and the complexity and heterogeneity of IBS patients make management difficult and unsatisfactory in many cases, reducing patient health-related quality of life and increasing the sanitary burden. This article reviews specific alterations and interventions targeting the gut microbiota in IBS, including prebiotics, probiotics, synbiotics, non-absorbable antibiotics, diets, fecal transplantation and other potential future approaches useful for the diagnosis, prevention and treatment of IBS. |
X Demographics
The data shown below were collected from the profiles of 12 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 2 | 17% |
| United Kingdom | 1 | 8% |
| Unknown | 9 | 75% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 50% |
| Practitioners (doctors, other healthcare professionals) | 4 | 33% |
| Science communicators (journalists, bloggers, editors) | 2 | 17% |
Mendeley readers
The data shown below were compiled from readership statistics for 481 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 481 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 95 | 20% |
| Researcher | 56 | 12% |
| Student > Master | 56 | 12% |
| Student > Ph. D. Student | 38 | 8% |
| Other | 36 | 7% |
| Other | 63 | 13% |
| Unknown | 137 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 80 | 17% |
| Nursing and Health Professions | 73 | 15% |
| Biochemistry, Genetics and Molecular Biology | 52 | 11% |
| Agricultural and Biological Sciences | 44 | 9% |
| Immunology and Microbiology | 18 | 4% |
| Other | 60 | 12% |
| Unknown | 154 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 25. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 July 2020.
All research outputs
#1,345,486
of 23,493,900 outputs
Outputs from Advances in Therapy
#107
of 2,407 outputs
Outputs of similar age
#31,624
of 332,299 outputs
Outputs of similar age from Advances in Therapy
#2
of 31 outputs
Altmetric has tracked 23,493,900 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,407 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one has done particularly well, scoring higher than 95% of its peers.
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We're also able to compare this research output to 31 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.