| Title |
A Tale of Two Citrullines—Structural and Functional Aspects of Myelin Basic Protein Deimination in Health and Disease
|
|---|---|
| Published in |
Neurochemical Research, August 2006
|
| DOI | 10.1007/s11064-006-9108-9 |
| Pubmed ID | |
| Authors |
George Harauz, Abdiwahab A. Musse |
| Abstract |
Myelin basic protein (MBP) binds to negatively charged lipids on the cytosolic surface of oligodendrocyte membranes and is responsible for adhesion of these surfaces in the multilayered myelin sheath. The pattern of extensive post-translational modifications of MBP is dynamic during normal central nervous system (CNS) development and during myelin degeneration in multiple sclerosis (MS), affecting its interactions with the myelin membranes and with other molecules. In particular, the degree of deimination (or citrullination) of MBP is correlated with the severity of MS, and may represent a primary defect that precedes neurodegeneration due to autoimmune attack. That the degree of MBP deimination is also high in early CNS development indicates that this modification plays major physiological roles in myelin assembly. In this review, we describe the structural and functional consequences of MBP deimination in healthy and diseased myelin. |
Mendeley readers
The data shown below were compiled from readership statistics for 86 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Finland | 1 | 1% |
| United Kingdom | 1 | 1% |
| Russia | 1 | 1% |
| Unknown | 83 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 29 | 34% |
| Researcher | 12 | 14% |
| Student > Master | 11 | 13% |
| Student > Bachelor | 10 | 12% |
| Student > Postgraduate | 5 | 6% |
| Other | 13 | 15% |
| Unknown | 6 | 7% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 27 | 31% |
| Biochemistry, Genetics and Molecular Biology | 15 | 17% |
| Medicine and Dentistry | 8 | 9% |
| Neuroscience | 7 | 8% |
| Immunology and Microbiology | 5 | 6% |
| Other | 16 | 19% |
| Unknown | 8 | 9% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 June 2023.
All research outputs
#2,658,179
of 24,041,016 outputs
Outputs from Neurochemical Research
#76
of 2,177 outputs
Outputs of similar age
#5,249
of 67,693 outputs
Outputs of similar age from Neurochemical Research
#2
of 12 outputs
Altmetric has tracked 24,041,016 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,177 research outputs from this source. They receive a mean Attention Score of 4.5. This one has done particularly well, scoring higher than 96% of its peers.
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We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.