Title |
Genetical genomic determinants of alcohol consumption in rats and humans
|
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Published in |
BMC Biology, October 2009
|
DOI | 10.1186/1741-7007-7-70 |
Pubmed ID | |
Authors |
Boris Tabakoff, Laura Saba, Morton Printz, Pam Flodman, Colin Hodgkinson, David Goldman, George Koob, Heather N Richardson, Katerina Kechris, Richard L Bell, Norbert Hübner, Matthias Heinig, Michal Pravenec, Jonathan Mangion, Lucie Legault, Maurice Dongier, Katherine M Conigrave, John B Whitfield, John Saunders, Bridget Grant, Paula L Hoffman, WHO/ISBRA Study on State and Trait Markers of Alcoholism |
Abstract |
We have used a genetical genomic approach, in conjunction with phenotypic analysis of alcohol consumption, to identify candidate genes that predispose to varying levels of alcohol intake by HXB/BXH recombinant inbred rat strains. In addition, in two populations of humans, we assessed genetic polymorphisms associated with alcohol consumption using a custom genotyping array for 1,350 single nucleotide polymorphisms (SNPs). Our goal was to ascertain whether our approach, which relies on statistical and informatics techniques, and non-human animal models of alcohol drinking behavior, could inform interpretation of genetic association studies with human populations. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 2 | 3% |
United States | 1 | 1% |
Spain | 1 | 1% |
Unknown | 73 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 17 | 22% |
Student > Ph. D. Student | 16 | 21% |
Student > Bachelor | 7 | 9% |
Professor > Associate Professor | 7 | 9% |
Student > Master | 7 | 9% |
Other | 13 | 17% |
Unknown | 10 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 23 | 30% |
Medicine and Dentistry | 10 | 13% |
Biochemistry, Genetics and Molecular Biology | 7 | 9% |
Neuroscience | 6 | 8% |
Psychology | 5 | 6% |
Other | 9 | 12% |
Unknown | 17 | 22% |