| Title |
A single injection of the kappa opioid antagonist norbinaltorphimine increases ethanol consumption in rats
|
|---|---|
| Published in |
Psychopharmacology, July 2005
|
| DOI | 10.1007/s00213-005-0067-7 |
| Pubmed ID | |
| Authors |
Jennifer M. Mitchell, Marisa T. Liang, Howard L. Fields |
| Abstract |
Kappa opioid receptor (KOR) agonists interfere with the reinforcing effects of drugs of abuse. KOR agonists decrease heroin, cocaine, and ethanol self-administration, and block heroin and cocaine conditioned place preference (CPP) in rats. However, KOR agonists also produce emesis and dysphoria, making it difficult to determine if their effects on self-administration are due to an action on reward mechanisms or are secondary to the drug's direct aversive effects. Assuming that endogenous KOR ligands modulate circuits involved in drug and alcohol reward, selective KOR antagonists can be used to clarify these issues. If KOR antagonists increase drug self-administration then it is likely that endogenous KOR agonists directly modulate drug intake. |
Mendeley readers
The data shown below were compiled from readership statistics for 51 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 4% |
| Argentina | 2 | 4% |
| Denmark | 1 | 2% |
| Unknown | 46 | 90% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 10 | 20% |
| Student > Bachelor | 6 | 12% |
| Student > Postgraduate | 5 | 10% |
| Student > Master | 5 | 10% |
| Student > Ph. D. Student | 4 | 8% |
| Other | 10 | 20% |
| Unknown | 11 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 16 | 31% |
| Medicine and Dentistry | 8 | 16% |
| Psychology | 6 | 12% |
| Neuroscience | 5 | 10% |
| Biochemistry, Genetics and Molecular Biology | 2 | 4% |
| Other | 2 | 4% |
| Unknown | 12 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 May 2017.
All research outputs
#8,882,501
of 26,017,215 outputs
Outputs from Psychopharmacology
#2,289
of 5,442 outputs
Outputs of similar age
#25,167
of 70,071 outputs
Outputs of similar age from Psychopharmacology
#21
of 44 outputs
Altmetric has tracked 26,017,215 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,442 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.0. This one is in the 28th percentile – i.e., 28% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 70,071 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 44 others from the same source and published within six weeks on either side of this one. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.