Title |
Upregulation of meiosis-specific genes in lymphoma cell lines following genotoxic insult and induction of mitotic catastrophe
|
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Published in |
BMC Cancer, January 2006
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DOI | 10.1186/1471-2407-6-6 |
Pubmed ID | |
Authors |
Martins Kalejs, Andrey Ivanov, Gregory Plakhins, Mark S Cragg, Dzintars Emzinsh, Timothy M Illidge, Jekaterina Erenpreisa |
Abstract |
We have previously reported that p53 mutated radioresistant lymphoma cell lines undergo mitotic catastrophe after irradiation, resulting in metaphase arrest and the generation of endopolyploid cells. A proportion of these endopolyploid cells then undergo a process of de-polyploidisation, stages of which are partially reminiscent of meiotic prophase. Furthermore, expression of meiosis-specific proteins of the cancer/testis antigens group of genes has previously been reported in tumours. We therefore investigated whether expression of meiosis-specific genes was associated with the polyploidy response in our tumour model. |
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Geographical breakdown
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Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 12 | 22% |
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Other | 3 | 5% |
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Unknown | 10 | 18% |