| Title |
The autoimmune lymphoproliferative syndrome: an experiment of nature involving lymphocyte apoptosis
|
|---|---|
| Published in |
Immunologic Research, September 2007
|
| DOI | 10.1007/s12026-007-8001-1 |
| Pubmed ID | |
| Authors |
Thomas A. Fleisher |
| Abstract |
Autoimmune lymphproliferative syndrome (ALPS) is a human disorder that has been characterized in the past two decades at both a functional and a genetic level. The underlying basis for this disorder is a defect in lymphocyte apoptosis that alters immune homeostasis resulting in an expansion of a normally rare circulating lymphocyte, the alpha beta double negative T cell. The abnormality in Fas mediated apoptosis underlying ALPS serves as a risk factor for autoimmunity involving blood cells and the development of lymphoma. There remain patients with a diagnosis of ALPS but without a defined genetic defect and current investigations are focusing on fully characterizing this patient subgroup. |
Mendeley readers
The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 4% |
| Germany | 1 | 4% |
| Unknown | 26 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 7 | 25% |
| Student > Ph. D. Student | 4 | 14% |
| Student > Doctoral Student | 4 | 14% |
| Student > Master | 3 | 11% |
| Student > Bachelor | 2 | 7% |
| Other | 7 | 25% |
| Unknown | 1 | 4% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 13 | 46% |
| Agricultural and Biological Sciences | 8 | 29% |
| Biochemistry, Genetics and Molecular Biology | 3 | 11% |
| Immunology and Microbiology | 2 | 7% |
| Neuroscience | 1 | 4% |
| Other | 0 | 0% |
| Unknown | 1 | 4% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 March 2008.
All research outputs
#7,453,479
of 22,786,691 outputs
Outputs from Immunologic Research
#277
of 904 outputs
Outputs of similar age
#24,871
of 69,926 outputs
Outputs of similar age from Immunologic Research
#1
of 3 outputs
Altmetric has tracked 22,786,691 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 904 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.0. This one is in the 46th percentile – i.e., 46% of its peers scored the same or lower than it.
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