Title |
[18F] AV-1451 uptake in corticobasal syndrome: the influence of beta-amyloid and clinical presentation
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Published in |
Journal of Neurology, March 2018
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DOI | 10.1007/s00415-018-8815-x |
Pubmed ID | |
Authors |
F. Ali, J. L. Whitwell, P. R. Martin, M. L. Senjem, D. S. Knopman, C. R. Jack, V. J. Lowe, R. C. Petersen, B. F. Boeve, K. A. Josephs |
Abstract |
Corticobasal syndrome (CBS) is a phenotypic manifestation of diverse pathologies, including Alzheimer's disease and 4-repeat tauopathies. Predicting pathology in CBS is unreliable and, hence, molecular neuroimaging may prove to be useful. The aim of this study was to assess regional patterns of uptake on [18F] AV-1451 PET in CBS and determine whether patterns of uptake differ according to beta-amyloid deposition or differing clinical presentations. Fourteen patients meeting criteria for CBS underwent Pittsburgh Compound B (PiB) and [18F] AV-1451 PET. Seven patients presented as CBS and seven presented with apraxia of speech (AOS) and later evolved into CBS. A global PiB summary was calculated and used to classify patients as PiB (-) or PiB (+). AV-1451 uptake was calculated in fourteen regions-of-interest, with values divided by uptake in cerebellar crus grey matter to generate standard uptake value ratios. AV-1451 uptake was considered elevated if it fell above the 95th percentile from a group of 476 cognitively unimpaired normal controls. Six of the 14 CBS patients (43%) were PiB (+), with three of these patients showing strikingly elevated AV-1451 uptake across many cortical regions. Of the eight PiB (-) patients, only those with AOS showed elevated AV-1451 uptake in supplementary motor area and precentral cortex compared to controls. No region of elevated AV-1451 uptake were observed in PiB (-) typical CBS patients without AOS. These results suggest that regional [18F] AV-1451 is variable in CBS and depends on the presence of beta-amyloid as well as clinical presentation such as AOS. PiB (+) CBS does not necessarily reflect underlying Alzheimer's disease; however, the possibility some of these patients will evolve into Alzheimer's disease over time cannot be excluded. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 50 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 10 | 20% |
Student > Master | 6 | 12% |
Student > Ph. D. Student | 6 | 12% |
Student > Doctoral Student | 3 | 6% |
Student > Bachelor | 3 | 6% |
Other | 10 | 20% |
Unknown | 12 | 24% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 15 | 30% |
Neuroscience | 7 | 14% |
Psychology | 4 | 8% |
Computer Science | 2 | 4% |
Agricultural and Biological Sciences | 1 | 2% |
Other | 5 | 10% |
Unknown | 16 | 32% |