| Title |
Phase and antigenic variation mediated by genome modifications
|
|---|---|
| Published in |
Antonie van Leeuwenhoek, July 2008
|
| DOI | 10.1007/s10482-008-9267-6 |
| Pubmed ID | |
| Authors |
Florence Wisniewski-Dyé, Ludovic Vial |
| Abstract |
Phase and antigenic variation is used by several bacterial species to generate intra-population diversity that increases bacterial fitness and is important in niche adaptation, or to escape host defences. By this adaptive process, bacteria undergo frequent and usually reversible phenotypic changes resulting from genetic or epigenetic alterations at specific genetic loci. Phase variation or phenotypic switch allows the expression of a given phenotype to be switched ON or OFF. Antigenic variation refers to the expression of a number of alternative forms of an antigen on the cell surface, and at a molecular level, shares common features with phase variation mechanisms. This review will focus on phase and antigenic variation mechanisms implying genome modifications, with an emphasis on the diversity of phenotypes regulated by these mechanisms, and the ecological relevance of variant appearance within a given population. |
Mendeley readers
The data shown below were compiled from readership statistics for 121 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 2% |
| Germany | 1 | <1% |
| Netherlands | 1 | <1% |
| Hungary | 1 | <1% |
| Lithuania | 1 | <1% |
| France | 1 | <1% |
| Argentina | 1 | <1% |
| United Kingdom | 1 | <1% |
| Unknown | 112 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 29 | 24% |
| Student > Ph. D. Student | 20 | 17% |
| Student > Master | 19 | 16% |
| Student > Bachelor | 11 | 9% |
| Student > Doctoral Student | 7 | 6% |
| Other | 19 | 16% |
| Unknown | 16 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 66 | 55% |
| Biochemistry, Genetics and Molecular Biology | 18 | 15% |
| Immunology and Microbiology | 6 | 5% |
| Medicine and Dentistry | 4 | 3% |
| Veterinary Science and Veterinary Medicine | 2 | 2% |
| Other | 6 | 5% |
| Unknown | 19 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 December 2020.
All research outputs
#7,453,479
of 22,786,691 outputs
Outputs from Antonie van Leeuwenhoek
#534
of 2,023 outputs
Outputs of similar age
#28,835
of 82,007 outputs
Outputs of similar age from Antonie van Leeuwenhoek
#1
of 2 outputs
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So far Altmetric has tracked 2,023 research outputs from this source. They receive a mean Attention Score of 3.6. This one is in the 42nd percentile – i.e., 42% of its peers scored the same or lower than it.
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We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them