| Title |
Medicolegal aspects of tetrazepam metabolism
|
|---|---|
| Published in |
International Journal of Legal Medicine, October 2006
|
| DOI | 10.1007/s00414-006-0118-6 |
| Pubmed ID | |
| Authors |
Marion Pavlic, Kathrin Libiseller, Petra Grubwieser, Heinrich Schubert, Walter Rabl |
| Abstract |
The benzodiazepine tetrazepam is primarily muscle relaxant with comparably lower central sedating effects and is therefore commonly prescribed for muscle spasms of different origins. To evaluate tetrazepam metabolism, a study was conducted with ten healthy volunteers. Blood and urine samples were regularly collected after the intake of 50 mg tetrazepam. Toxicological analyses revealed that tetrazepam is also metabolized to diazepam and further to nordazepam, which has not yet been reported. Tetrazepam and diazepam could be detected in urine samples at least 72 h after intake, the diazepam concentration being 33% (+/-14% SD), on average, of the tetrazepam concentration. On the basis of three case histories, the importance of the detection of these newly described metabolites is shown as necessary to prevent false accusations and potential negative legal consequences for examined persons. |
Mendeley readers
The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Argentina | 1 | 10% |
| Unknown | 9 | 90% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 4 | 40% |
| Student > Bachelor | 2 | 20% |
| Student > Ph. D. Student | 2 | 20% |
| Student > Master | 1 | 10% |
| Student > Doctoral Student | 1 | 10% |
| Other | 0 | 0% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 4 | 40% |
| Agricultural and Biological Sciences | 2 | 20% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 10% |
| Medicine and Dentistry | 1 | 10% |
| Social Sciences | 1 | 10% |
| Other | 0 | 0% |
| Unknown | 1 | 10% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 August 2020.
All research outputs
#7,453,479
of 22,786,691 outputs
Outputs from International Journal of Legal Medicine
#394
of 2,061 outputs
Outputs of similar age
#23,286
of 66,787 outputs
Outputs of similar age from International Journal of Legal Medicine
#4
of 7 outputs
Altmetric has tracked 22,786,691 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,061 research outputs from this source. They receive a mean Attention Score of 4.6. This one has gotten more attention than average, scoring higher than 68% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 66,787 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.