| Title |
Activation of hypoxia-inducible factor-1 regulates human histidine decarboxylase expression
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, March 2009
|
| DOI | 10.1007/s00018-009-9001-1 |
| Pubmed ID | |
| Authors |
H. J. Jeong, P. D. Moon, S. J. Kim, J. U. Seo, T. H. Kang, J. J. Kim, I. C. Kang, J. Y. Um, H. M. Kim, S. H. Hong |
| Abstract |
Histidine decarboxylase (HDC) catalyzes the formation of histamine from histidine. Histamine has various effects in physiological and pathological reactions, such as inflammation, cell growth, and neuro-transmission. We investigated the role of hypoxia-inducible factor (HIF)-1 on hypoxia-induced HDC expression in human mast cell line, HMC-1 cells and mouse bone marrow-derived mast cells (BMMCs). Hypoxia significantly increased histamine production. HDC expression and activity were induced by hypoxia. Additionally, when cells were transfected with a native form of HIF-1alpha, hypoxia could induce higher HDC expression than in the nontransfected cell. HIF-1 binding activity for HDC 5' flanking region (HFR) was similar to that for the hypoxia-responsive element. Using HDC promoter deletion analysis, we also demonstrated that HFR was regulated by HIF-1 activation. In addition, depletion of HIF-1alpha prevents hypoxic induction of HDC in BMMCs. In conclusion, these results demonstrate that hypoxia induces HDC expression by transcriptional mechanisms dependent upon HIF-1. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 15% |
| Japan | 1 | 4% |
| Unknown | 22 | 81% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 10 | 37% |
| Student > Master | 6 | 22% |
| Researcher | 3 | 11% |
| Professor | 2 | 7% |
| Professor > Associate Professor | 2 | 7% |
| Other | 3 | 11% |
| Unknown | 1 | 4% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 11 | 41% |
| Sports and Recreations | 5 | 19% |
| Biochemistry, Genetics and Molecular Biology | 3 | 11% |
| Nursing and Health Professions | 1 | 4% |
| Environmental Science | 1 | 4% |
| Other | 3 | 11% |
| Unknown | 3 | 11% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 September 2022.
All research outputs
#7,444,575
of 24,495,755 outputs
Outputs from Cellular and Molecular Life Sciences
#1,849
of 5,616 outputs
Outputs of similar age
#32,739
of 97,472 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#14
of 36 outputs
Altmetric has tracked 24,495,755 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 5,616 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one has gotten more attention than average, scoring higher than 66% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 97,472 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 36 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.