| Title |
Medicinal mushroom modulators of molecular targets as cancer therapeutics
|
|---|---|
| Published in |
Applied Microbiology and Biotechnology, February 2005
|
| DOI | 10.1007/s00253-004-1787-z |
| Pubmed ID | |
| Authors |
Ben-Zion Zaidman, Majed Yassin, Jamal Mahajna, Solomon P. Wasser |
| Abstract |
Empirical approaches to discover anticancer drugs and cancer treatments have made limited progress in the past several decades in finding a cure for cancer. The expanded knowledge of the molecular basis of tumorigenesis and metastasis, together with the inherently vast structural diversity of natural compounds found in mushrooms, provided unique opportunities for discovering new drugs that rationally target the abnormal molecular and biochemical signals leading to cancer. This review focuses on mushroom low-molecular-weight secondary metabolites targeting processes such as apoptosis, angiogenesis, metastasis, cell cycle regulation, and signal transduction cascades. Also discussed in this review are high-molecular-weight polysaccharides or polysaccharide-protein complexes from mushrooms that appear to enhance innate and cell-mediated immune responses, exhibit antitumor activities in animals and humans, and demonstrate the anticancer properties of selenium compounds accumulated in mushrooms. |
X Demographics
The data shown below were collected from the profiles of 27 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 19% |
| Mexico | 1 | 4% |
| Colombia | 1 | 4% |
| Austria | 1 | 4% |
| China | 1 | 4% |
| Spain | 1 | 4% |
| Ireland | 1 | 4% |
| United Kingdom | 1 | 4% |
| Australia | 1 | 4% |
| Other | 0 | 0% |
| Unknown | 14 | 52% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 18 | 67% |
| Practitioners (doctors, other healthcare professionals) | 4 | 15% |
| Scientists | 3 | 11% |
| Science communicators (journalists, bloggers, editors) | 2 | 7% |
Mendeley readers
The data shown below were compiled from readership statistics for 228 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 1 | <1% |
| Brazil | 1 | <1% |
| Israel | 1 | <1% |
| Taiwan | 1 | <1% |
| China | 1 | <1% |
| Japan | 1 | <1% |
| Unknown | 222 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 45 | 20% |
| Researcher | 35 | 15% |
| Student > Bachelor | 30 | 13% |
| Student > Ph. D. Student | 20 | 9% |
| Student > Postgraduate | 11 | 5% |
| Other | 40 | 18% |
| Unknown | 47 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 80 | 35% |
| Biochemistry, Genetics and Molecular Biology | 26 | 11% |
| Medicine and Dentistry | 22 | 10% |
| Chemistry | 15 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 10 | 4% |
| Other | 27 | 12% |
| Unknown | 48 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 26. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 March 2024.
All research outputs
#1,517,890
of 25,641,627 outputs
Outputs from Applied Microbiology and Biotechnology
#86
of 8,349 outputs
Outputs of similar age
#2,022
of 74,744 outputs
Outputs of similar age from Applied Microbiology and Biotechnology
#1
of 59 outputs
Altmetric has tracked 25,641,627 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 8,349 research outputs from this source. They receive a mean Attention Score of 4.4. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 74,744 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 59 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.