| Title |
Molecular diversification in spider venoms: A web of combinatorial peptide libraries
|
|---|---|
| Published in |
Molecular Diversity, November 2006
|
| DOI | 10.1007/s11030-006-9050-4 |
| Pubmed ID | |
| Authors |
Pierre Escoubas |
| Abstract |
Spider venoms are a rich source of novel pharmacologically and agrochemically interesting compounds that have received increased attention from pharmacologists and biochemists in recent years. The application of technologies derived from genomics and proteomics have led to the discovery of the enormous molecular diversity of those venoms, which consist mainly of peptides and proteins. The molecular diversity of spider peptides has been revealed by mass spectrometry and appears to be based on a limited set of structural scaffolds. Genetic analysis has led to a further understanding of the molecular evolution mechanisms presiding over the generation of these combinatorial peptide libraries. Gene duplication and focal hypermutation, which has been described in cone snails, appear to be common mechanisms to venomous mollusks and spiders. Post-translational modifications, fine structural variations and new molecular scaffolds are other potential mechanisms of toxin diversification, leading to the pharmacologically complex cocktails used for predation and defense. |
Mendeley readers
The data shown below were compiled from readership statistics for 69 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 3% |
| Russia | 1 | 1% |
| Australia | 1 | 1% |
| Brazil | 1 | 1% |
| Unknown | 64 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 17% |
| Researcher | 10 | 14% |
| Student > Master | 8 | 12% |
| Student > Bachelor | 8 | 12% |
| Professor > Associate Professor | 7 | 10% |
| Other | 13 | 19% |
| Unknown | 11 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 32 | 46% |
| Chemistry | 7 | 10% |
| Biochemistry, Genetics and Molecular Biology | 5 | 7% |
| Medicine and Dentistry | 3 | 4% |
| Unspecified | 2 | 3% |
| Other | 5 | 7% |
| Unknown | 15 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 April 2018.
All research outputs
#3,272,132
of 22,786,691 outputs
Outputs from Molecular Diversity
#33
of 463 outputs
Outputs of similar age
#7,533
of 69,214 outputs
Outputs of similar age from Molecular Diversity
#1
of 1 outputs
Altmetric has tracked 22,786,691 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 463 research outputs from this source. They receive a mean Attention Score of 3.2. This one has done well, scoring higher than 89% of its peers.
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We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them