| Title |
Biosynthesis of cobalamin (vitamin B12): a bacterial conundrum
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, December 2000
|
| DOI | 10.1007/pl00000670 |
| Pubmed ID | |
| Authors |
E. Raux, H. L. Schubert, M. J. Warren* |
| Abstract |
The biosynthesis of cobalamin (vitamin B12) is described, revealing how the concerted action of around 30 enzyme-mediated steps results in the synthesis of one of Nature's most structurally complex 'small molecules'. The plethora of genome sequences has meant that bacteria capable of cobalamin synthesis can be easily identified and their biosynthetic genes compared. Whereas only a few years ago cobalamin synthesis was thought to occur by one of two routes, there are apparently a number of variations on these two pathways, where the major differences seem to be concerned with the process of ring contraction. A comparison of what is currently known about these pathways is presented. Finally, the process of cobalt chelation is discussed and the structure/function of the cobalt chelatase associated with the oxygen-independent pathway (CbiK) is described. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 254 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 1% |
| Portugal | 1 | <1% |
| Netherlands | 1 | <1% |
| Germany | 1 | <1% |
| India | 1 | <1% |
| Australia | 1 | <1% |
| Unknown | 246 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 62 | 24% |
| Researcher | 41 | 16% |
| Student > Master | 32 | 13% |
| Student > Bachelor | 31 | 12% |
| Student > Doctoral Student | 13 | 5% |
| Other | 39 | 15% |
| Unknown | 36 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 94 | 37% |
| Biochemistry, Genetics and Molecular Biology | 49 | 19% |
| Chemistry | 18 | 7% |
| Environmental Science | 16 | 6% |
| Engineering | 8 | 3% |
| Other | 27 | 11% |
| Unknown | 42 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 June 2018.
All research outputs
#7,538,708
of 25,837,817 outputs
Outputs from Cellular and Molecular Life Sciences
#1,944
of 5,993 outputs
Outputs of similar age
#21,954
of 115,812 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#12
of 20 outputs
Altmetric has tracked 25,837,817 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 5,993 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.9. This one has gotten more attention than average, scoring higher than 66% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 115,812 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 78% of its contemporaries.
We're also able to compare this research output to 20 others from the same source and published within six weeks on either side of this one. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.