Title |
Nutritional support in multimodal therapy for cancer cachexia
|
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Published in |
Supportive Care in Cancer, January 2008
|
DOI | 10.1007/s00520-007-0388-7 |
Pubmed ID | |
Authors |
Ingvar Bosaeus |
Abstract |
Malnutrition has since long been known to be associated with adverse outcomes in cancer patients. The wasting in cancer cachexia involves loss of muscle and fat and reflects a catabolic metabolism induced by an abnormal host response to tumour presence and/or tumour factors. Patients with cancer cachexia frequently develop a chronic negative energy and protein balance driven by a combination of reduced food intake and metabolic change. Thus, alterations in both energy intake and components of energy expenditure may contribute to progressive weight loss. Increased resting energy expenditure related to the systemic inflammatory response is common and a sustained hypermetabolism over a long period of disease progression can make a large contribution to negative energy balance and wasting if not compensated for by an increase in energy intake. Hypermetabolism and diminished energy intake due to anorexia may thus constitute a vicious circle in the development of cancer cachexia. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 1% |
United Kingdom | 1 | <1% |
Spain | 1 | <1% |
Australia | 1 | <1% |
Unknown | 142 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 34 | 23% |
Student > Ph. D. Student | 18 | 12% |
Researcher | 15 | 10% |
Other | 13 | 9% |
Student > Bachelor | 11 | 7% |
Other | 32 | 22% |
Unknown | 24 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 60 | 41% |
Nursing and Health Professions | 17 | 12% |
Agricultural and Biological Sciences | 11 | 7% |
Psychology | 7 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 4% |
Other | 16 | 11% |
Unknown | 30 | 20% |