| Title |
Feasibility of state of the art PET/CT systems performance harmonisation
|
|---|---|
| Published in |
European Journal of Nuclear Medicine and Molecular Imaging, March 2018
|
| DOI | 10.1007/s00259-018-3977-4 |
| Pubmed ID | |
| Authors |
Andres Kaalep, Terez Sera, Sjoerd Rijnsdorp, Maqsood Yaqub, Anne Talsma, Martin A. Lodge, Ronald Boellaard |
| Abstract |
The objective of this study was to explore the feasibility of harmonising performance for PET/CT systems equipped with time-of-flight (ToF) and resolution modelling/point spread function (PSF) technologies. A second aim was producing a working prototype of new harmonising criteria with higher contrast recoveries than current EARL standards using various SUV metrics. Four PET/CT systems with both ToF and PSF capabilities from three major vendors were used to acquire and reconstruct images of the NEMA NU2-2007 body phantom filled conforming EANM EARL guidelines. A total of 15 reconstruction parameter sets of varying pixel size, post filtering and reconstruction type, with three different acquisition durations were used to compare the quantitative performance of the systems. A target range for recovery curves was established such that it would accommodate the highest matching recoveries from all investigated systems. These updated criteria were validated on 18 additional scanners from 16 sites in order to demonstrate the scanners' ability to meet the new target range. Each of the four systems was found to be capable of producing harmonising reconstructions with similar recovery curves. The five reconstruction parameter sets producing harmonising results significantly increased SUVmean (25%) and SUVmax (26%) contrast recoveries compared with current EARL specifications. Additional prospective validation performed on 18 scanners from 16 EARL accredited sites demonstrated the feasibility of updated harmonising specifications. SUVpeak was found to significantly reduce the variability in quantitative results while producing lower recoveries in smaller (≤17 mm diameter) sphere sizes. Harmonising PET/CT systems with ToF and PSF technologies from different vendors was found to be feasible. The harmonisation of such systems would require an update to the current multicentre accreditation program EARL in order to accommodate higher recoveries. SUVpeak should be further investigated as a noise resistant alternative quantitative metric to SUVmax. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 50% |
| Canada | 1 | 25% |
| Unknown | 1 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 2 | 50% |
| Members of the public | 2 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 138 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 138 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 21 | 15% |
| Other | 18 | 13% |
| Student > Ph. D. Student | 17 | 12% |
| Student > Master | 17 | 12% |
| Student > Bachelor | 10 | 7% |
| Other | 19 | 14% |
| Unknown | 36 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 39 | 28% |
| Physics and Astronomy | 21 | 15% |
| Engineering | 10 | 7% |
| Nursing and Health Professions | 7 | 5% |
| Computer Science | 3 | 2% |
| Other | 17 | 12% |
| Unknown | 41 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 November 2018.
All research outputs
#14,092,097
of 24,293,076 outputs
Outputs from European Journal of Nuclear Medicine and Molecular Imaging
#1,925
of 3,388 outputs
Outputs of similar age
#169,180
of 335,158 outputs
Outputs of similar age from European Journal of Nuclear Medicine and Molecular Imaging
#23
of 46 outputs
Altmetric has tracked 24,293,076 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,388 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one is in the 43rd percentile – i.e., 43% of its peers scored the same or lower than it.
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We're also able to compare this research output to 46 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.