| Title |
Rodent models of focal stroke: Size, mechanism, and purpose
|
|---|---|
| Published in |
Neurotherapeutics, July 2005
|
| DOI | 10.1602/neurorx.2.3.396 |
| Pubmed ID | |
| Authors |
S. Thomas Carmichael |
| Abstract |
Rodent stroke models provide the experimental backbone for the in vivo determination of the mechanisms of cell death and neural repair, and for the initial testing of neuroprotective compounds. Less than 10 rodent models of focal stroke are routinely used in experimental study. These vary widely in their ability to model the human disease, and in their application to the study of cell death or neural repair. Many rodent focal stroke models produce large infarcts that more closely resemble malignant and fatal human infarction than the average sized human stroke. This review focuses on the mechanisms of ischemic damage in rat and mouse stroke models, the relative size of stroke generated in each model, and the purpose with which focal stroke models are applied to the study of ischemic cell death and to neural repair after stroke. |
Mendeley readers
The data shown below were compiled from readership statistics for 641 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | <1% |
| Canada | 5 | <1% |
| Germany | 4 | <1% |
| United Kingdom | 3 | <1% |
| Malaysia | 1 | <1% |
| Netherlands | 1 | <1% |
| Indonesia | 1 | <1% |
| Latvia | 1 | <1% |
| Hong Kong | 1 | <1% |
| Other | 9 | 1% |
| Unknown | 609 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 161 | 25% |
| Researcher | 99 | 15% |
| Student > Bachelor | 76 | 12% |
| Student > Master | 69 | 11% |
| Student > Doctoral Student | 35 | 5% |
| Other | 122 | 19% |
| Unknown | 79 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 148 | 23% |
| Neuroscience | 143 | 22% |
| Medicine and Dentistry | 112 | 17% |
| Biochemistry, Genetics and Molecular Biology | 39 | 6% |
| Engineering | 32 | 5% |
| Other | 55 | 9% |
| Unknown | 112 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 July 2023.
All research outputs
#3,798,287
of 25,373,627 outputs
Outputs from Neurotherapeutics
#422
of 1,308 outputs
Outputs of similar age
#7,518
of 67,857 outputs
Outputs of similar age from Neurotherapeutics
#3
of 8 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,308 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.2. This one has gotten more attention than average, scoring higher than 66% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 67,857 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 5 of them.