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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Dense genotyping of immune-related susceptibility loci reveals new insights into the genetics of psoriatic arthritis
|
|---|---|
| Published in |
Nature Communications, February 2015
|
| DOI | 10.1038/ncomms7046 |
| Pubmed ID | |
| Authors |
John Bowes, Ashley Budu-Aggrey, Ulrike Huffmeier, Steffen Uebe, Kathryn Steel, Harry L. Hebert, Chris Wallace, Jonathan Massey, Ian N. Bruce, James Bluett, Marie Feletar, Ann W. Morgan, Helena Marzo-Ortega, Gary Donohoe, Derek W. Morris, Philip Helliwell, Anthony W. Ryan, David Kane, Richard B. Warren, Eleanor Korendowych, Gerd-Marie Alenius, Emiliano Giardina, Jonathan Packham, Ross McManus, Oliver FitzGerald, Neil McHugh, Matthew A. Brown, Pauline Ho, Frank Behrens, Harald Burkhardt, Andre Reis, Anne Barton |
| Abstract |
Psoriatic arthritis (PsA) is a chronic inflammatory arthritis associated with psoriasis and, despite the larger estimated heritability for PsA, the majority of genetic susceptibility loci identified to date are shared with psoriasis. Here, we present results from a case-control association study on 1,962 PsA patients and 8,923 controls using the Immunochip genotyping array. We identify eight loci passing genome-wide significance, secondary independent effects at three loci and a distinct PsA-specific variant at the IL23R locus. We report two novel loci and evidence of a novel PsA-specific association at chromosome 5q31. Imputation of classical HLA alleles, amino acids and SNPs across the MHC region highlights three independent associations to class I genes. Finally, we find an enrichment of associated variants to markers of open chromatin in CD8(+) memory primary T cells. This study identifies key insights into the genetics of PsA that could begin to explain fundamental differences between psoriasis and PsA. |
X Demographics
The data shown below were collected from the profiles of 18 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 2 | 11% |
| Belgium | 1 | 6% |
| France | 1 | 6% |
| United Kingdom | 1 | 6% |
| Sweden | 1 | 6% |
| Ireland | 1 | 6% |
| Unknown | 11 | 61% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 15 | 83% |
| Scientists | 2 | 11% |
| Science communicators (journalists, bloggers, editors) | 1 | 6% |
Mendeley readers
The data shown below were compiled from readership statistics for 173 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | 2% |
| Netherlands | 1 | <1% |
| Ireland | 1 | <1% |
| Australia | 1 | <1% |
| Unknown | 167 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 33 | 19% |
| Student > Ph. D. Student | 27 | 16% |
| Student > Bachelor | 16 | 9% |
| Student > Master | 16 | 9% |
| Other | 15 | 9% |
| Other | 28 | 16% |
| Unknown | 38 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 45 | 26% |
| Biochemistry, Genetics and Molecular Biology | 25 | 14% |
| Agricultural and Biological Sciences | 23 | 13% |
| Immunology and Microbiology | 17 | 10% |
| Chemistry | 4 | 2% |
| Other | 16 | 9% |
| Unknown | 43 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 49. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 October 2016.
All research outputs
#835,472
of 24,892,887 outputs
Outputs from Nature Communications
#13,922
of 54,439 outputs
Outputs of similar age
#11,461
of 363,181 outputs
Outputs of similar age from Nature Communications
#141
of 656 outputs
Altmetric has tracked 24,892,887 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 54,439 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.9. This one has gotten more attention than average, scoring higher than 74% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 363,181 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 656 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.