| Title |
Cyclin A in cell cycle control and cancer
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, August 2002
|
| DOI | 10.1007/s00018-002-8510-y |
| Pubmed ID | |
| Authors |
C. H. Yam, T. K. Fung, R. Y. C. Poon |
| Abstract |
Cyclin A is particularly interesting among the cyclin family because it can activate two different cyclin-dependent kinases (CDKs) and functions in both S phase and mitosis. An embryonic form of cyclin A that is only essential for spermatogenesis is also present in some organisms. In S phase, phosphorylation of components of the DNA replication machinery such as CDC6 by cyclin A-CDK is believed to be important for initiation of DNA replication and to restrict the initiation to only once per cell cycle. In mitosis, the precise role of cyclin A is still obscure, but it may contribute to the control of cyclin B stability. Cyclin A starts to accumulate during S phase and is abruptly destroyed before metaphase. The synthesis of cyclin A is mainly controlled at the transcription level, involving E2F and other transcription factors. Removal of cyclin A is carried out by ubiquitin-mediated proteolysis, but whether the same anaphase-promoting complex/cyclosome targeting subunits are used as for cyclin B is debatable. Consistent with its role as a key cell cycle regulator, expression of cyclin A is found to be elevated in a variety of tumors. |
Mendeley readers
The data shown below were compiled from readership statistics for 284 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Croatia | 1 | <1% |
| Spain | 1 | <1% |
| Unknown | 282 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 56 | 20% |
| Student > Bachelor | 40 | 14% |
| Unspecified | 37 | 13% |
| Student > Master | 33 | 12% |
| Student > Doctoral Student | 19 | 7% |
| Other | 42 | 15% |
| Unknown | 57 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 69 | 24% |
| Biochemistry, Genetics and Molecular Biology | 64 | 23% |
| Unspecified | 37 | 13% |
| Medicine and Dentistry | 31 | 11% |
| Neuroscience | 5 | 2% |
| Other | 18 | 6% |
| Unknown | 60 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 January 2022.
All research outputs
#2,260,312
of 23,794,258 outputs
Outputs from Cellular and Molecular Life Sciences
#276
of 4,151 outputs
Outputs of similar age
#2,387
of 45,584 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#1
of 12 outputs
Altmetric has tracked 23,794,258 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,151 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 45,584 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.