| Title |
Pulmonary hemodynamics responses to hypoxia and/or CO2 inhalation during moderate exercise in humans
|
|---|---|
| Published in |
Pflügers Archiv - European Journal of Physiology, March 2018
|
| DOI | 10.1007/s00424-018-2127-y |
| Pubmed ID | |
| Authors |
Stéphane Doutreleau, Irina Enache, Cristina Pistea, Bernard Geny, Anne Charloux |
| Abstract |
In this study, we hypothesized that adding CO2to an inhaled hypoxic gas mixture will limit the rise of pulmonary artery pressure (PAP) induced by a moderate exercise. Eight 20-year-old males performed four constant-load exercise tests on cycle at 40% of maximal oxygen consumption in four conditions: ambient air, normobaric hypoxia (12.5% O2), inhaled CO2(4.5% CO2), and combination of hypoxia and inhaled CO2. Doppler echocardiography was used to measure systolic (s)PAP, cardiac output (CO). Total pulmonary resistance (TPR) was calculated. Arterialized blood pH was 7.40 at exercise in ambient and hypoxia conditions, whereas CO2inhalation and combined conditions showed acidosis. sPAP increases from rest in ambient air to exercise ranged as follows: ambient + 110%, CO2inhalation + 135%, combined + 184%, hypoxia + 217% (p < 0.001). CO was higher when inhaling O2-poor gas mixtures with or without CO2(~ 17 L min-1) than in the other conditions (~ 14 L min-1, p < 0.001). Exercise induced a significant decrease in TPR in the four conditions (p < 0.05) but less marked in hypoxia (- 19% of the resting value in ambient air) than in ambient (- 33%) and in both CO2inhalation and combined condition (- 29%). We conclude that (1) acute CO2inhalation did not significantly modify pulmonary hemodynamics during moderate exercise. (2) CO2adjunction to hypoxic gas mixture did not modify CO, despite a higher CaO2in combined condition than in hypoxia. (3) TPR was lower in combined than in hypoxia condition, limiting sPAP increase in combined condition. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 24 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 3 | 13% |
| Student > Master | 2 | 8% |
| Student > Ph. D. Student | 2 | 8% |
| Student > Doctoral Student | 2 | 8% |
| Unspecified | 1 | 4% |
| Other | 2 | 8% |
| Unknown | 12 | 50% |
| Readers by discipline | Count | As % |
|---|---|---|
| Sports and Recreations | 4 | 17% |
| Medicine and Dentistry | 3 | 13% |
| Unspecified | 1 | 4% |
| Computer Science | 1 | 4% |
| Nursing and Health Professions | 1 | 4% |
| Other | 2 | 8% |
| Unknown | 12 | 50% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 March 2018.
All research outputs
#19,221,261
of 23,818,521 outputs
Outputs from Pflügers Archiv - European Journal of Physiology
#1,557
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Outputs of similar age
#260,524
of 333,477 outputs
Outputs of similar age from Pflügers Archiv - European Journal of Physiology
#15
of 17 outputs
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