| Title |
Pattern of metastasis and outcome in patients with breast cancer
|
|---|---|
| Published in |
Clinical & Experimental Metastasis, January 2015
|
| DOI | 10.1007/s10585-015-9697-2 |
| Pubmed ID | |
| Authors |
L. Gerratana, V. Fanotto, M. Bonotto, S. Bolzonello, A. M. Minisini, G. Fasola, F. Puglisi |
| Abstract |
There is growing evidence about differences in metastatic spread among breast cancer (BC) biologic subtypes (BS). Aim of this study was to analyze the pattern of metastasization according to BS and to explore the corresponding prognosis. A series of 544 consecutive patients receiving anticancer therapy for metastatic BC from 2004 to 2013, was analyzed. BS were defined by immunohistochemistry according to St Gallen 2013 criteria. Association between BS and the different distant localizations was analyzed. Prognosis was described in terms of overall survival (OS), progression free survival (PFS) and post progression survival (PPS). Results were reported taking luminal A BC as reference. Triple negative BC showed a higher tropism for lung (OR 4.30 95 % CI 1.41-13.1), while non luminal HER2 subtype was associated with a higher rate of liver metastases (OR 3.61 95 % CI 1.36-9.58). All subtypes were associated with a lower risk of bone-only localization. Central nervous system (CNS) involvement was more common in HER2 positive BC (OR 6.3, 95 % CI 1.08-36.66). Liver, lung and CNS involvement influenced negatively OS (HR 1.64, 95 % CI 1.29-2.07; HR 1.49, 95 % CI 1.18-1.90; HR 2.891, 95 % CI 1.85-4.51, respectively) and PFS (HR 1.39, 95 % CI 1.13-1.71; HR 1.26, 95 % CI 1.02-1.55; HR 1.75, 95 % CI 1.12-2.71, respectively). Multivariate analysis confirmed liver involvement as independent predictor of worse OS (HR 1.64, 95 % CI 1.15-2.34). Stratification by metastatic pattern showed significant differences in terms of PPS but not in terms of PFS. The study suggests that BS may be characterized by typical patterns of metastatic spread and have different impact on clinical outcome. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Italy | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 168 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 2 | 1% |
| Portugal | 1 | <1% |
| Colombia | 1 | <1% |
| Unknown | 164 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 28 | 17% |
| Student > Bachelor | 22 | 13% |
| Student > Master | 18 | 11% |
| Researcher | 17 | 10% |
| Other | 13 | 8% |
| Other | 23 | 14% |
| Unknown | 47 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 54 | 32% |
| Biochemistry, Genetics and Molecular Biology | 20 | 12% |
| Agricultural and Biological Sciences | 10 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 9 | 5% |
| Immunology and Microbiology | 5 | 3% |
| Other | 17 | 10% |
| Unknown | 53 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 April 2024.
All research outputs
#7,381,450
of 23,854,458 outputs
Outputs from Clinical & Experimental Metastasis
#186
of 778 outputs
Outputs of similar age
#99,442
of 359,601 outputs
Outputs of similar age from Clinical & Experimental Metastasis
#2
of 10 outputs
Altmetric has tracked 23,854,458 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 778 research outputs from this source. They receive a mean Attention Score of 4.0. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 359,601 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 8 of them.