| Title |
Three-dimensionally plotted MBG/PHBHHx composite scaffold for antitubercular drug delivery and tissue regeneration
|
|---|---|
| Published in |
Journal of Materials Science: Materials in Medicine, February 2015
|
| DOI | 10.1007/s10856-015-5455-x |
| Pubmed ID | |
| Authors |
Kun Li, Min Zhu, Peng Xu, Yanhai Xi, Zisheng Cheng, Yufang Zhu, Xiaojian Ye |
| Abstract |
A suitable drug-loaded scaffold that can postoperatively release an antituberculosis drug efficiently in a lesion area and help repair a bone defect is very important in the clinical treatment of bone tuberculosis (TB). In this study, a composite drug-loaded cylindrical scaffold was prepared by using three-dimensional printing technology in combination with the mesoporous confinement range, surface chemical groups, and gradual degradation of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate). This achieves the slow release of a drug for as long as possible. We implanted the drug-loaded compound scaffold into New Zealand rabbits' femur defect model to study the in vivo drug release performance and osteogenic ability. The in vivo release of isoniazid and rifampicin from the prepared composites could be effectively sustained for 12 weeks in local tissues, whereas these drugs were sustained for just 2 weeks in a control group. The blood drug concentrations were very low and most concentrations were below 5 μg/ml. Therefore, the systemic toxic adverse effect is very low. In addition, the composite exhibits good osteogenic potential in a rabbit bone defect model. The results of this study indicate that this composite has great potential for treating osteoarticular TB. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 69 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 69 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 17% |
| Student > Master | 8 | 12% |
| Student > Doctoral Student | 7 | 10% |
| Researcher | 5 | 7% |
| Student > Postgraduate | 4 | 6% |
| Other | 10 | 14% |
| Unknown | 23 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 10 | 14% |
| Engineering | 9 | 13% |
| Materials Science | 7 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 6% |
| Chemistry | 2 | 3% |
| Other | 7 | 10% |
| Unknown | 30 | 43% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 February 2015.
All research outputs
#14,799,522
of 22,786,691 outputs
Outputs from Journal of Materials Science: Materials in Medicine
#1,013
of 1,400 outputs
Outputs of similar age
#198,525
of 352,111 outputs
Outputs of similar age from Journal of Materials Science: Materials in Medicine
#19
of 48 outputs
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So far Altmetric has tracked 1,400 research outputs from this source. They receive a mean Attention Score of 3.4. This one is in the 25th percentile – i.e., 25% of its peers scored the same or lower than it.
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We're also able to compare this research output to 48 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.