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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Sudden Death in Heart Failure With Preserved Ejection Fraction A Competing Risks Analysis From the TOPCAT Trial
|
|---|---|
| Published in |
JACC: Heart Failure, March 2018
|
| DOI | 10.1016/j.jchf.2018.02.014 |
| Pubmed ID | |
| Authors |
Muthiah Vaduganathan, Brian L Claggett, Neal A Chatterjee, Inder S Anand, Nancy K Sweitzer, James C Fang, Eileen O'Meara, Sanjiv J Shah, Sheila M Hegde, Akshay S Desai, Eldrin F Lewis, Jean Rouleau, Bertram Pitt, Marc A Pfeffer, Scott D Solomon |
| Abstract |
Sudden death (SD) may be an important mode of death in heart failure with preserved ejection fraction (HFpEF). To investigate rates and predictors of SD or aborted cardiac arrest (ACA) in HFpEF. We studied 1,767 patients with HFpEF (EF≥45%) enrolled in the Americas region of the TOPCAT trial. We identified independent predictors of composite SD/ACA with step-wise backward selection using competing risks regression analysis accounting for non-sudden causes of death. During median 3.0 (1.9-4.4) year follow-up, 77 patients experienced SD/ACA and 312 experienced non-SD/ACA. Corresponding incidence rates were 1.4 (1.1-1.8) and 5.8 (5.1-6.4) events/100 patient-years. SD/ACA was numerically lower but not statistically reduced in those randomized to spironolactone: 1.2 (0.9-1.7) vs. 1.6 (1.2-2.2) events/100 patient-years; subdistributional HR 0.74 95% CI 0.47-1.16; P=0.19. After accounting for competing risks of non-sudden death, male sex and insulin-treated diabetes mellitus were independently predictive of composite SD/ACA (C-statistic 0.65). Covariates-including eligibility criteria, age, ejection fraction, coronary artery disease, LBBB, and baseline therapies-were not independently associated with SD/ACA. Sex and diabetes mellitus status remained independent predictors in sensitivity analyses excluding patients with implantable cardioverter-defibrillators and when predicting SD alone. SD accounted for ∼20% of deaths in HFpEF. Male sex and insulin-treated diabetes mellitus identify patients at higher risk for SD/ACA with modest discrimination. These data may guide future SD-preventative efforts in HFpEF. TOPCAT (Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist); ClinicalTrials.gov Unique Identifier: NCT00094302. |
X Demographics
The data shown below were collected from the profiles of 103 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 19 | 18% |
| United States | 11 | 11% |
| Venezuela, Bolivarian Republic of | 7 | 7% |
| Mexico | 5 | 5% |
| Argentina | 5 | 5% |
| France | 3 | 3% |
| Colombia | 2 | 2% |
| Italy | 1 | <1% |
| Germany | 1 | <1% |
| Other | 12 | 12% |
| Unknown | 37 | 36% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 71 | 69% |
| Practitioners (doctors, other healthcare professionals) | 17 | 17% |
| Science communicators (journalists, bloggers, editors) | 10 | 10% |
| Scientists | 5 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 72 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 72 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 8 | 11% |
| Student > Master | 7 | 10% |
| Student > Bachelor | 6 | 8% |
| Student > Doctoral Student | 5 | 7% |
| Researcher | 5 | 7% |
| Other | 12 | 17% |
| Unknown | 29 | 40% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 26 | 36% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
| Nursing and Health Professions | 2 | 3% |
| Mathematics | 1 | 1% |
| Biochemistry, Genetics and Molecular Biology | 1 | 1% |
| Other | 5 | 7% |
| Unknown | 35 | 49% |
Attention Score in Context
This research output has an Altmetric Attention Score of 54. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 December 2018.
All research outputs
#784,274
of 25,382,440 outputs
Outputs from JACC: Heart Failure
#231
of 1,583 outputs
Outputs of similar age
#17,853
of 347,103 outputs
Outputs of similar age from JACC: Heart Failure
#6
of 43 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,583 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 30.2. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 347,103 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 43 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.