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Mendeley readers
Attention Score in Context
| Title |
Benign Familial Neonatal Convulsions Caused by Altered Gating of KCNQ2/KCNQ3 Potassium Channels
|
|---|---|
| Published in |
Journal of Neuroscience, January 2002
|
| DOI | 10.1523/jneurosci.22-02-j0003.2002 |
| Pubmed ID | |
| Authors |
Pasqualina Castaldo, Emanuele Miraglia del Giudice, Giangennaro Coppola, Antonio Pascotto, Lucio Annunziato, Maurizio Taglialatela |
| Abstract |
The muscarinic-regulated potassium current (M-current), formed by the heteromeric assembly of subunits encoded by the KCNQ2 and KCNQ3 genes, is a primary regulator of neuronal excitability; this regulation is accomplished by impeding repetitive firing and causing spike-frequency adaptation. Mutations in KCNQ2 or KCNQ3 cause benign familial neonatal convulsions (BFNC), a rare autosomal-dominant generalized epilepsy of newborns, by reducing the maximal current carried by the M-channels without affecting ion selectivity or gating properties. Here we show that KCNQ2/KCNQ3 channels carrying a novel BFNC-causing mutation leading to an arginine to tryptophan substitution in the voltage-sensing S4 domain of KCNQ2 subunits (R214W) displayed slower opening and faster closing kinetics and a decreased voltage sensitivity with no concomitant changes in maximal current or plasma membrane expression. These results suggest that mutation-induced gating alterations of the M-current may cause epilepsy in neonates. |
Mendeley readers
The data shown below were compiled from readership statistics for 61 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 3% |
| Germany | 1 | 2% |
| Sweden | 1 | 2% |
| Austria | 1 | 2% |
| Japan | 1 | 2% |
| United States | 1 | 2% |
| Unknown | 54 | 89% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 13 | 21% |
| Professor > Associate Professor | 10 | 16% |
| Researcher | 8 | 13% |
| Student > Bachelor | 7 | 11% |
| Professor | 5 | 8% |
| Other | 7 | 11% |
| Unknown | 11 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 15 | 25% |
| Medicine and Dentistry | 11 | 18% |
| Neuroscience | 7 | 11% |
| Biochemistry, Genetics and Molecular Biology | 5 | 8% |
| Psychology | 3 | 5% |
| Other | 4 | 7% |
| Unknown | 16 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 May 2008.
All research outputs
#8,537,346
of 25,377,790 outputs
Outputs from Journal of Neuroscience
#12,459
of 24,135 outputs
Outputs of similar age
#36,310
of 142,178 outputs
Outputs of similar age from Journal of Neuroscience
#60
of 152 outputs
Altmetric has tracked 25,377,790 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 24,135 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.8. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 142,178 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 152 others from the same source and published within six weeks on either side of this one. This one is in the 21st percentile – i.e., 21% of its contemporaries scored the same or lower than it.