Title |
Involvement of corneodesmosome degradation and lamellar granule transportation in the desquamation process
|
---|---|
Published in |
Medical Molecular Morphology, March 2011
|
DOI | 10.1007/s00795-010-0513-4 |
Pubmed ID | |
Authors |
Akemi Ishida-Yamamoto, Mari Kishibe |
Abstract |
Desquamation in the mammalian skin is a well-balanced process of producing corneocytes and shedding them from the surface of the skin. The corneodesmosome, which is a modified desmosome, is the main adhesive structure in the cornified cell layer. The major extracellular constituents of corneodesmosomes are desmoglein 1, desmocollin 1, and corneodesmosin. Proteases involved in the degradation of corneodesmosomes and their inhibitors are secreted from lamellar granules in the granular cell layer. Genetic defects in corneodesmosin and protease inhibitors result in accelerated desquamation and severe barrier impairment. Abnormalities in transportation and secretion of lamellar granules underlie ichthyosis seen in certain human diseases. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 1 | 3% |
Netherlands | 1 | 3% |
Unknown | 37 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 10 | 26% |
Student > Ph. D. Student | 6 | 15% |
Student > Master | 6 | 15% |
Student > Doctoral Student | 3 | 8% |
Student > Bachelor | 2 | 5% |
Other | 6 | 15% |
Unknown | 6 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 15 | 38% |
Biochemistry, Genetics and Molecular Biology | 6 | 15% |
Medicine and Dentistry | 5 | 13% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 8% |
Chemistry | 2 | 5% |
Other | 3 | 8% |
Unknown | 5 | 13% |