Title |
Receptor communication within the lymphocyte plasma membrane: a role for the thrombospondin family of matricellular proteins
|
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Published in |
Cellular and Molecular Life Sciences, December 2006
|
DOI | 10.1007/s00018-006-6255-8 |
Pubmed ID | |
Authors |
A. Forslöw, Z. Liu, K. -G. Sundqvist |
Abstract |
Lymphocytes, the principal cells of the immune system, carry out immune surveillance throughout the body by their unique capacity to constantly reposition themselves between a free-floating vascular state and a tissue state characterized by migration and frequent adhesive interactions with endothelial cells and components of the extracellular matrix. Therefore, mechanisms co-ordinating adhesion and migration with signals delivered through antigen recognition probably play a pivotal role for the regulation of lymphocyte behaviour and function. Endogenous thrombospondin-1 (TSP-1) seems to be the hub in such a mechanism for autocrine regulation of T cell adhesion and migration. TSP-1 functions as a mediator of cis interaction of vital receptors within the T lymphocyte plasma membrane, including integrins, low density lipoprotein receptor-related protein, calreticulin and integrin-associated protein. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Hungary | 1 | 5% |
Unknown | 19 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 6 | 30% |
Student > Ph. D. Student | 5 | 25% |
Student > Bachelor | 2 | 10% |
Professor | 1 | 5% |
Lecturer > Senior Lecturer | 1 | 5% |
Other | 2 | 10% |
Unknown | 3 | 15% |
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---|---|---|
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Biochemistry, Genetics and Molecular Biology | 1 | 5% |
Other | 2 | 10% |
Unknown | 2 | 10% |