| Title |
Interaction of green tea polyphenol epigallocatechin-3-gallate with sunitinib: potential risk of diminished sunitinib bioavailability
|
|---|---|
| Published in |
Journal of Molecular Medicine, February 2011
|
| DOI | 10.1007/s00109-011-0737-3 |
| Pubmed ID | |
| Authors |
Jun Ge, Ben-Xu Tan, Ye Chen, Li Yang, Xing-Chen Peng, Hong-Ze Li, Hong-Jun Lin, Yu Zhao, Meng Wei, Ke Cheng, Long-Hao Li, Hang Dong, Feng Gao, Jian-Ping He, Yang Wu, Meng Qiu, Ying-Lan Zhao, Jing-Mei Su, Jian-Mei Hou, Ji-Yan Liu |
| Abstract |
Sunitinib, a novel oral multi-targeted tyrosine kinase inhibitor for patients with metastatic renal cell carcinoma (mRCC) and advanced gastrointestinal stromal tumor, has a good prospect for clinical application and is being investigated for the potential therapy of other tumors. We observed the phenomenon that drinking tea interfered with symptom control in an mRCC patient treated with sunitinib and speculated that green tea or its components might interact with sunitinib. This study was performed to investigate whether epigallocatechin-3-gallate (EGCG), the major constituent of green tea, interacted with sunitinib. The interaction between EGCG and sunitinib was examined in vitro and in vivo. (1)H nuclear magnetic resonance ((1)H-NMR) spectroscopy and mass spectrometry (MS) were used to analyze the interaction between these two molecules and whether a new compound was formed. Solutions of sunitinib and EGCG were intragastrically administered to rats to investigate whether the plasma concentrations of sunitinib were affected by EGCG. In this study, we noticed that a precipitate was formed when the solutions of sunitinib and EGCG were mixed under both neutral and acidic conditions. (1)H-NMR spectra indicated an interaction between EGCG and sunitinib, but no new compound was observed by MS. Sticky semisolid contents were found in the stomachs of sunitinib and EGCG co-administrated mice. The AUC(0-∞) and C (max) of plasma sunitinib were markedly reduced by co-administration of EGCG to rats. Our study firstly showed that EGCG interacted with sunitinib and reduced the bioavailability of sunitinib. This finding has significant practical implications for tea-drinking habit during sunitinib administration. |
Mendeley readers
The data shown below were compiled from readership statistics for 62 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 62 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 12 | 19% |
| Student > Bachelor | 8 | 13% |
| Other | 7 | 11% |
| Student > Ph. D. Student | 7 | 11% |
| Student > Master | 6 | 10% |
| Other | 8 | 13% |
| Unknown | 14 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 18 | 29% |
| Biochemistry, Genetics and Molecular Biology | 7 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 10% |
| Nursing and Health Professions | 4 | 6% |
| Agricultural and Biological Sciences | 4 | 6% |
| Other | 3 | 5% |
| Unknown | 20 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 December 2021.
All research outputs
#7,453,479
of 22,786,691 outputs
Outputs from Journal of Molecular Medicine
#504
of 1,551 outputs
Outputs of similar age
#38,655
of 106,489 outputs
Outputs of similar age from Journal of Molecular Medicine
#8
of 15 outputs
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