Title |
Selectivity of repaglinide and glibenclamide for the pancreatic over the cardiovascular KATP channels
|
---|---|
Published in |
Diabetologia, July 2006
|
DOI | 10.1007/s00125-006-0307-3 |
Pubmed ID | |
Authors |
D. Stephan, M. Winkler, P. Kühner, U. Russ, U. Quast |
Abstract |
Sulfonylureas and glinides close beta cell ATP-sensitive K(+) (K(ATP)) channels to increase insulin release; the concomitant closure of cardiovascular K(ATP) channels, however, leads to complications in patients with cardiac ischaemia. The insulinotrope repaglinide is successful in therapy, but has been reported to inhibit the recombinant K(ATP) channels of beta cells, cardiocytes and non-vascular smooth muscle cells with similar potencies, suggesting that the (patho-)physiological role of the cardiovascular K(ATP) channels may be overstated. We therefore re-examined repaglinide's potency at and affinity for the recombinant pancreatic, myocardial and vascular K(ATP) channels in comparison with glibenclamide. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 2% |
Unknown | 40 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 7 | 17% |
Student > Master | 7 | 17% |
Student > Bachelor | 4 | 10% |
Researcher | 4 | 10% |
Student > Doctoral Student | 3 | 7% |
Other | 7 | 17% |
Unknown | 9 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 10 | 24% |
Biochemistry, Genetics and Molecular Biology | 5 | 12% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 10% |
Medicine and Dentistry | 4 | 10% |
Engineering | 2 | 5% |
Other | 5 | 12% |
Unknown | 11 | 27% |