Title |
Drug therapy for acquired pendular nystagmus in multiple sclerosis
|
---|---|
Published in |
Journal of Neurology, November 1996
|
DOI | 10.1007/pl00007728 |
Pubmed ID | |
Authors |
M. Starck, H. Albrecht, W. Pöllmann, A. Straube, M. Dieterich |
Abstract |
Acquired pendular nystagmus (APN) is regularly accompanied by oscillopsia and impairment of static visual acuity. Therapeutic approaches to APN remain controversial, and there is no generally accepted therapeutic approach. We tested 14 patients who had suffered from APN caused by multiple sclerosis for several years; 12 patients presented with fixational pendular nystagmus (increasing during fixation) and 2 with spontaneous pendular nystagmus. All 11 patients with fixational pendular nystagmus who were given memantine, a glutamate antagonist, experienced complete cessation of the nystagmus. In contrast, scopolamine caused no (6 of 8) or only a minor (10-50%) reduction of the nystagmus (2 of 8). It was concluded that memantine is a safe treatment option for APN. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 3% |
Unknown | 34 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 6 | 17% |
Researcher | 5 | 14% |
Other | 4 | 11% |
Professor | 3 | 9% |
Professor > Associate Professor | 3 | 9% |
Other | 9 | 26% |
Unknown | 5 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 10 | 29% |
Agricultural and Biological Sciences | 6 | 17% |
Psychology | 5 | 14% |
Neuroscience | 4 | 11% |
Physics and Astronomy | 1 | 3% |
Other | 2 | 6% |
Unknown | 7 | 20% |