| Title |
Mitochondrial respiratory chain in the colonic mucosal of patients with ulcerative colitis
|
|---|---|
| Published in |
Molecular and Cellular Biochemistry, May 2010
|
| DOI | 10.1007/s11010-010-0474-x |
| Pubmed ID | |
| Authors |
Karla G. Sifroni, Carlos R. Damiani, Cristhopher Stoffel, Mariane R. Cardoso, Gabriela K. Ferreira, Isabela C. Jeremias, Gislaine T. Rezin, Giselli Scaini, Patricia F. Schuck, Felipe Dal-Pizzol, Emilio L. Streck |
| Abstract |
Ulcerative colitis (UC) is a chronic inflammatory disease of the large bowel. Its pathogenesis remains unclear, but it appears to result from a deregulated immune response, with infiltration of leukocytes into the mucosal interstitium. Several studies link oxidative stress and mitochondrial dysfunction to the pathogenesis of UC. Thus, the aim of this study was to evaluate the activities of mitochondrial respiratory chain complexes in the colonic mucosal of UC patients. Colonic biopsies were obtained from UC patients (n = 13). The control specimens were taken from patients without any history of inflammatory bowel disease (n = 8). Colon mucosal was removed by colonoscopy and homogenized. Mitochondrial respiratory chain complexes activities were then measured. Our results showed that the activity of complex I was not altered in UC patients, when compared to the control group. On the other hand, complexes II, III, and IV were decreased around 50-60% in the colonic mucosal of UC patients. Based on the present findings, we hypothesize that mitochondrial dysfunction may play a role in pathogenesis of UC. |
Mendeley readers
The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Austria | 1 | 2% |
| Unknown | 43 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 9 | 20% |
| Student > Master | 7 | 16% |
| Researcher | 7 | 16% |
| Student > Bachelor | 5 | 11% |
| Student > Doctoral Student | 2 | 5% |
| Other | 4 | 9% |
| Unknown | 10 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 13 | 30% |
| Medicine and Dentistry | 8 | 18% |
| Biochemistry, Genetics and Molecular Biology | 7 | 16% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 5% |
| Sports and Recreations | 2 | 5% |
| Other | 1 | 2% |
| Unknown | 11 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 July 2018.
All research outputs
#7,453,479
of 22,786,691 outputs
Outputs from Molecular and Cellular Biochemistry
#417
of 2,301 outputs
Outputs of similar age
#34,428
of 95,243 outputs
Outputs of similar age from Molecular and Cellular Biochemistry
#2
of 13 outputs
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We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.