| Title |
Physiological functions of D-amino acid oxidases: from yeast to humans
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, March 2007
|
| DOI | 10.1007/s00018-007-6558-4 |
| Pubmed ID | |
| Authors |
L. Pollegioni, L. Piubelli, S. Sacchi, M. S. Pilone, G. Molla |
| Abstract |
D-Amino acid oxidase (DAAO) is a FAD-containing flavoenzyme that catalyzes the oxidative deamination of D-isomers of neutral and polar amino acids. This enzymatic activity has been identified in most eukaryotic organisms, the only exception being plants. In the various organisms in which it does occur, DAAO fulfills distinct physiological functions: from a catabolic role in yeast cells, which allows them to grow on D-amino acids as carbon and energy sources, to a regulatory role in the human brain, where it controls the levels of the neuromodulator D-serine. Since 1935, DAAO has been the object of an astonishing number of investigations and has become a model for the dehydrogenase-oxidase class of flavoproteins. Structural and functional studies have suggested that specific physiological functions are implemented through the use of different structural elements that control access to the active site and substrate/product exchange. Current research is attempting to delineate the regulation of DAAO functions in the contest of complex biochemical and physiological networks. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Latvia | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 210 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 2 | <1% |
| Russia | 2 | <1% |
| United Kingdom | 1 | <1% |
| Japan | 1 | <1% |
| Poland | 1 | <1% |
| Unknown | 203 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 49 | 23% |
| Researcher | 31 | 15% |
| Student > Bachelor | 25 | 12% |
| Student > Master | 23 | 11% |
| Other | 7 | 3% |
| Other | 31 | 15% |
| Unknown | 44 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 68 | 32% |
| Biochemistry, Genetics and Molecular Biology | 49 | 23% |
| Chemistry | 17 | 8% |
| Neuroscience | 6 | 3% |
| Medicine and Dentistry | 5 | 2% |
| Other | 23 | 11% |
| Unknown | 42 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 October 2021.
All research outputs
#3,297,540
of 23,794,258 outputs
Outputs from Cellular and Molecular Life Sciences
#506
of 4,151 outputs
Outputs of similar age
#8,814
of 78,509 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#7
of 38 outputs
Altmetric has tracked 23,794,258 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,151 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 78,509 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 38 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.