Title |
Light-driven DNA repair by photolyases
|
---|---|
Published in |
Cellular and Molecular Life Sciences, May 2006
|
DOI | 10.1007/s00018-005-5447-y |
Pubmed ID | |
Authors |
L. O. Essen, T. Klar |
Abstract |
DNA photolyases are highly efficient light-driven DNA repair enzymes which revert the genome-damaging effects caused by ultraviolet (UV) radiation. These enzymes occur in almost all living organisms exposed to sunlight, the only exception being placental mammals like humans and mice. Their catalytic mechanism employs the light-driven injection of an electron onto the DNA lesion to trigger the cleavage of cyclobutane- pyrimidine dimers or 6-4 photoproducts inside duplex DNA. Spectroscopic and structural analysis has recently yielded a concise view of how photolyases recognize these DNA lesions involving two neighboring bases, catalyze the repair reaction within a nanosecond and still achieve quantum efficiencies of close to one. Apart from these mechanistic aspects, the potential of DNA photolyases for the generation of highly UV-resistant organisms, or for skin cancer prevention by ectopical application is increasingly recognized. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Portugal | 1 | <1% |
Germany | 1 | <1% |
Netherlands | 1 | <1% |
Norway | 1 | <1% |
United Kingdom | 1 | <1% |
Spain | 1 | <1% |
United States | 1 | <1% |
Luxembourg | 1 | <1% |
Unknown | 174 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 48 | 26% |
Student > Master | 33 | 18% |
Student > Bachelor | 28 | 15% |
Researcher | 23 | 13% |
Student > Doctoral Student | 9 | 5% |
Other | 22 | 12% |
Unknown | 19 | 10% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 56 | 31% |
Biochemistry, Genetics and Molecular Biology | 47 | 26% |
Chemistry | 22 | 12% |
Physics and Astronomy | 8 | 4% |
Immunology and Microbiology | 6 | 3% |
Other | 20 | 11% |
Unknown | 23 | 13% |