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Mendeley readers
Attention Score in Context
| Title |
Molecular Cloning of ILP-2, a Novel Member of the Inhibitor of Apoptosis Protein Family
|
|---|---|
| Published in |
Molecular & Cellular Biology, March 2023
|
| DOI | 10.1128/mcb.21.13.4292-4301.2001 |
| Pubmed ID | |
| Authors |
Bettina W. M. Richter, Samy S. Mir, Lisa J. Eiben, Jennifer Lewis, Stephanie Birkey Reffey, Annalisa Frattini, Lan Tian, Stephan Frank, Richard J. Youle, David L. Nelson, Luigi D. Notarangelo, Paolo Vezzoni, Howard O. Fearnhead, Colin S. Duckett |
| Abstract |
Inhibitor of apoptosis protein (IAP)-like protein-1 (ILP-1) (also known as X-linked IAP [XIAP] and mammalian IAP homolog A [MIHA]) is a potent inhibitor of apoptosis and exerts its effects, at least in part, by the direct association with and inhibition of specific caspases. Here, we describe the molecular cloning and characterization of a human gene related to ILP-1, termed ILP-2. Despite high homology to ILP-1, ILP-2 is encoded by a distinct gene, which in normal tissues is expressed solely in testis. In contrast to ILP-1, overexpression of ILP-2 had no protective effect on apoptosis mediated by Fas (also known as CD95) or tumor necrosis factor. However, ILP-2 potently inhibited apoptosis induced by overexpression of Bax or by coexpression of caspase 9 with Apaf-1, and preincubation of cytosolic extracts with ILP-2 abrogated caspase activation in vitro. A processed form of caspase 9 could be coprecipitated with ILP-2 from cells, suggesting a physical interaction between ILP-2 and caspase 9. Thus, ILP-2 is a novel IAP family member with restricted specificity for caspase 9. |
Mendeley readers
The data shown below were compiled from readership statistics for 51 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 4% |
| Germany | 1 | 2% |
| Unknown | 48 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 9 | 18% |
| Researcher | 7 | 14% |
| Student > Master | 6 | 12% |
| Other | 5 | 10% |
| Student > Doctoral Student | 4 | 8% |
| Other | 8 | 16% |
| Unknown | 12 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 15 | 29% |
| Biochemistry, Genetics and Molecular Biology | 12 | 24% |
| Chemistry | 3 | 6% |
| Medicine and Dentistry | 3 | 6% |
| Immunology and Microbiology | 2 | 4% |
| Other | 3 | 6% |
| Unknown | 13 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 February 2024.
All research outputs
#8,535,684
of 25,374,917 outputs
Outputs from Molecular & Cellular Biology
#4,291
of 11,892 outputs
Outputs of similar age
#150,083
of 421,655 outputs
Outputs of similar age from Molecular & Cellular Biology
#3,243
of 8,975 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 11,892 research outputs from this source. They receive a mean Attention Score of 4.5. This one is in the 13th percentile – i.e., 13% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 421,655 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.
We're also able to compare this research output to 8,975 others from the same source and published within six weeks on either side of this one. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.