| Title |
Pharmacokinetics, oral bioavailability, and metabolic profile of resveratrol and its dimethylether analog, pterostilbene, in rats
|
|---|---|
| Published in |
Cancer Chemotherapy and Pharmacology, November 2010
|
| DOI | 10.1007/s00280-010-1525-4 |
| Pubmed ID | |
| Authors |
Izet M. Kapetanovic, Miguel Muzzio, Zhihua Huang, Thomas N. Thompson, David L. McCormick |
| Abstract |
Resveratrol (3,5,4'-trihydroxy-trans-stilbene) is a naturally occurring polyphenol with a broad range of possible health benefits, including anti-cancer activity. However, the biological activity of resveratrol may be limited by poor absorption and first-pass metabolism: only low plasma concentrations of resveratrol are seen following oral administration, and metabolism to glucuronide and sulfate conjugates is rapid. Methylated polyphenol analogs (such as pterostilbene [3,5-dimethoxy-4'-hydroxy-trans-stilbene], the dimethylether analog of resveratrol) may overcome these limitations to pharmacologic efficacy. The present study was designed to compare the bioavailability, pharmacokinetics, and metabolism of resveratrol and pterostilbene following equimolar oral dosing in rats. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 258 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | <1% |
| Portugal | 1 | <1% |
| Sweden | 1 | <1% |
| Brazil | 1 | <1% |
| Spain | 1 | <1% |
| United Kingdom | 1 | <1% |
| Unknown | 251 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 47 | 18% |
| Student > Bachelor | 35 | 14% |
| Researcher | 33 | 13% |
| Student > Master | 29 | 11% |
| Student > Doctoral Student | 16 | 6% |
| Other | 41 | 16% |
| Unknown | 57 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 52 | 20% |
| Pharmacology, Toxicology and Pharmaceutical Science | 35 | 14% |
| Biochemistry, Genetics and Molecular Biology | 30 | 12% |
| Medicine and Dentistry | 20 | 8% |
| Chemistry | 20 | 8% |
| Other | 29 | 11% |
| Unknown | 72 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 July 2023.
All research outputs
#4,873,161
of 24,051,764 outputs
Outputs from Cancer Chemotherapy and Pharmacology
#233
of 2,510 outputs
Outputs of similar age
#31,152
of 186,457 outputs
Outputs of similar age from Cancer Chemotherapy and Pharmacology
#2
of 17 outputs
Altmetric has tracked 24,051,764 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,510 research outputs from this source. They receive a mean Attention Score of 4.1. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 186,457 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.