Title |
Uteroferrin contains complex and high mannose-type oligosaccharides when synthesized in vitro
|
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Published in |
Molecular and Cellular Biochemistry, September 1991
|
DOI | 10.1007/bf00227750 |
Pubmed ID | |
Authors |
George A. Baumbach, Philippa T. K. Saunders, Catherine M. Ketcham, Fuller W. Bazer, R. Michael Roberts |
Abstract |
Mature uteroferrin (Uf; Mr = 35,500) is a progesterone-induced acid phosphatase secreted by the pig uterus. It contains a single, unphosphorylated, high mannose-type oligosaccharide. Endometrial explants cultured in vitro secrete Uf with a Mr of 37,000 (37k Uf) having phosphorylated high mannose oligosaccharides. In this report we demonstrate that 37k Uf contains two N-linked oligosaccharides which are a mixture of complex and high mannose-type oligosaccharides. The complex-type glycopeptides are biantennary and a portion may be fucosylated on the GlcNac of the chitobiose core proximal to the peptide. Only a portion of the high mannose-type oligosaccharides are phosphorylated. The remainder appear to be typical Man6-4GlcNac2 oligosaccharides found on mature Uf. |
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