Title |
The full spectrum of human naive T cells
|
---|---|
Published in |
Nature Reviews Immunology, March 2018
|
DOI | 10.1038/s41577-018-0001-y |
Pubmed ID | |
Authors |
Theo van den Broek, José A. M. Borghans, Femke van Wijk |
Abstract |
Naive T cells have long been regarded as a developmentally synchronized and fairly homogeneous and quiescent cell population, the size of which depends on age, thymic output and prior infections. However, there is increasing evidence that naive T cells are heterogeneous in phenotype, function, dynamics and differentiation status. Current strategies to identify naive T cells should be adjusted to take this heterogeneity into account. Here, we provide an integrated, revised view of the naive T cell compartment and discuss its implications for healthy ageing, neonatal immunity and T cell reconstitution following haematopoietic stem cell transplantation. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 18 | 18% |
United Kingdom | 7 | 7% |
Netherlands | 4 | 4% |
Spain | 4 | 4% |
Switzerland | 3 | 3% |
Sweden | 3 | 3% |
Australia | 3 | 3% |
Singapore | 2 | 2% |
Saudi Arabia | 2 | 2% |
Other | 21 | 21% |
Unknown | 33 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 57 | 57% |
Scientists | 36 | 36% |
Practitioners (doctors, other healthcare professionals) | 4 | 4% |
Science communicators (journalists, bloggers, editors) | 3 | 3% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 691 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 125 | 18% |
Researcher | 111 | 16% |
Student > Master | 81 | 12% |
Student > Bachelor | 62 | 9% |
Other | 41 | 6% |
Other | 92 | 13% |
Unknown | 179 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Immunology and Microbiology | 157 | 23% |
Biochemistry, Genetics and Molecular Biology | 128 | 19% |
Agricultural and Biological Sciences | 76 | 11% |
Medicine and Dentistry | 75 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 8 | 1% |
Other | 47 | 7% |
Unknown | 200 | 29% |