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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Structure–Activity Relationships of GAG Mimetic-Functionalized Mesoporous Silica Nanoparticles and Evaluation of Acyclovir-Loaded Antiviral Nanoparticles with Dual Mechanisms of Action
|
|---|---|
| Published in |
ACS Omega, February 2018
|
| DOI | 10.1021/acsomega.7b01662 |
| Pubmed ID | |
| Authors |
Edward C. Lee, Chau T. H. Nguyen, Ekaterina Strounina, Nicholas Davis-Poynter, Benjamin P. Ross |
| Abstract |
Mesoporous silica nanoparticles (MSNs) are drug delivery agents that are able to incorporate drugs within their pores. Furthermore, MSNs can be functionalized by attachment of bioactive ligands on their surface to enhance their activity, and nanoparticles modified with glycosaminoglycan (GAG) mimetics inhibit the entry of herpes simplex virus (HSV) into cells. In this study, structure-activity relationships of GAGs attached to MSNs were investigated in relation to HSV-1 and HSV-2, and acyclovir was loaded into the pores of MSNs. The sulfonate group was demonstrated to be essential for antiviral activity, which was enhanced by incorporating a benzene group within the ligand. Loading acyclovir into GAG mimetic-functionalized MSNs reduced the viral infection, resulting in nanoparticles that simultaneously target two distinct viral pathways, namely, inhibition of viral entry and inhibition of DNA replication. |
X Demographics
The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 4 | 50% |
| Saudi Arabia | 1 | 13% |
| Hong Kong | 1 | 13% |
| Unknown | 2 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 63% |
| Scientists | 3 | 38% |
Mendeley readers
The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 37 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 11 | 30% |
| Student > Bachelor | 4 | 11% |
| Student > Master | 3 | 8% |
| Other | 3 | 8% |
| Researcher | 3 | 8% |
| Other | 2 | 5% |
| Unknown | 11 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 7 | 19% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 11% |
| Chemical Engineering | 2 | 5% |
| Agricultural and Biological Sciences | 2 | 5% |
| Materials Science | 2 | 5% |
| Other | 4 | 11% |
| Unknown | 16 | 43% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 October 2018.
All research outputs
#6,300,178
of 25,382,440 outputs
Outputs from ACS Omega
#977
of 7,296 outputs
Outputs of similar age
#119,041
of 451,567 outputs
Outputs of similar age from ACS Omega
#28
of 173 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,296 research outputs from this source. They receive a mean Attention Score of 4.9. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 451,567 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 173 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.