| Title |
Control of infection by pyroptosis and autophagy: role of TLR and NLR
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, March 2010
|
| DOI | 10.1007/s00018-010-0335-5 |
| Pubmed ID | |
| Authors |
Karina R. Bortoluci, Ruslan Medzhitov |
| Abstract |
Cells can die by distinct mechanisms with particular impacts on the immune response. In addition to apoptosis and necrosis, recent studies lead to characterization of a new pro-inflammatory form of cell death, pyroptosis. TLR and NLR, central innate immune sensors, can control infections by modulating host cell survival. In addition, TLRs can promote the induction of autophagy, thus promoting delivery of infecting pathogens to the lysosomes. On the other hand, activation of some NLR members, especially NLRC4 and NAIP5, leads to the infected cell death by pyroptosis, which is accompanied by secretion of the pro-inflammatory cytokines IL-1beta, IL-18, and IL-33. Data presented here illustrate how the compartmentalization of the innate immune sensors can influence the outcome of infections by controlling the fate of host cells. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 212 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 2% |
| Brazil | 3 | 1% |
| United Kingdom | 3 | 1% |
| Germany | 2 | <1% |
| Canada | 1 | <1% |
| Kazakhstan | 1 | <1% |
| Japan | 1 | <1% |
| Mexico | 1 | <1% |
| Unknown | 195 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 58 | 27% |
| Researcher | 39 | 18% |
| Student > Master | 23 | 11% |
| Professor > Associate Professor | 21 | 10% |
| Student > Doctoral Student | 11 | 5% |
| Other | 39 | 18% |
| Unknown | 21 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 89 | 42% |
| Medicine and Dentistry | 32 | 15% |
| Biochemistry, Genetics and Molecular Biology | 28 | 13% |
| Immunology and Microbiology | 19 | 9% |
| Veterinary Science and Veterinary Medicine | 4 | 2% |
| Other | 15 | 7% |
| Unknown | 25 | 12% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 May 2022.
All research outputs
#7,315,081
of 23,794,258 outputs
Outputs from Cellular and Molecular Life Sciences
#1,552
of 4,151 outputs
Outputs of similar age
#33,532
of 95,887 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#11
of 27 outputs
Altmetric has tracked 23,794,258 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 4,151 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has gotten more attention than average, scoring higher than 62% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 95,887 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.
We're also able to compare this research output to 27 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 59% of its contemporaries.