| Title |
The genetic backgrounds in nonalcoholic fatty liver disease
|
|---|---|
| Published in |
Clinical Journal of Gastroenterology, February 2018
|
| DOI | 10.1007/s12328-018-0841-9 |
| Pubmed ID | |
| Authors |
Yuya Seko, Kanji Yamaguchi, Yoshito Itoh |
| Abstract |
Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease worldwide. Nonalcoholic steatohepatitis (NASH), a severe form of NAFLD, can lead to hepatocellular carcinoma (HCC) and hepatic failure. The development and progression of NAFLD are determined by environmental and genetic factors. The effect of genetic factors has been demonstrated by familial studies, twin studies and several cross-sectional studies. In the past 10 years, genome-wide association studies have revealed several single nucleotide polymorphisms (SNPs) associated with the pathology of NAFLD. Among them, the Patatin-like phospholipase domain-containing 3 (PNPLA3) gene variant I148M showed a strong relationship with the development and progression of NAFLD, NASH, and NAFLD-related HCC. The transmembrane 6 superfamily member 2 (TM6SF2) gene variant E167 K was also associated with NAFLD, and it has a relationship with cardiovascular disease. Furthermore, several genes have been proposed as candidate genes to be associated with NAFLD based on case-control studies. We conducted a comprehensive literature search and review on the genetic background of NAFLD. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 86 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 86 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 13 | 15% |
| Student > Bachelor | 12 | 14% |
| Student > Ph. D. Student | 11 | 13% |
| Student > Master | 11 | 13% |
| Student > Postgraduate | 6 | 7% |
| Other | 16 | 19% |
| Unknown | 17 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 32 | 37% |
| Agricultural and Biological Sciences | 11 | 13% |
| Biochemistry, Genetics and Molecular Biology | 9 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 5% |
| Nursing and Health Professions | 4 | 5% |
| Other | 2 | 2% |
| Unknown | 24 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 August 2018.
All research outputs
#2,445,320
of 23,567,572 outputs
Outputs from Clinical Journal of Gastroenterology
#10
of 429 outputs
Outputs of similar age
#53,221
of 331,509 outputs
Outputs of similar age from Clinical Journal of Gastroenterology
#1
of 8 outputs
Altmetric has tracked 23,567,572 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 429 research outputs from this source. They receive a mean Attention Score of 2.3. This one has done particularly well, scoring higher than 97% of its peers.
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We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them