| Title |
ZnT-8, A Pancreatic Beta-Cell-Specific Zinc Transporter
|
|---|---|
| Published in |
BioMetals, August 2005
|
| DOI | 10.1007/s10534-005-3687-9 |
| Pubmed ID | |
| Authors |
Fabrice Chimienti, Alain Favier, Michel Seve |
| Abstract |
The zinc content in the pancreatic beta cell is among the highest of the body. Zinc appears to be an important metal for insulin-secreting cells as insulin is stored inside secretory vesicles as a solid hexamer bound with two Zn(2+) ions per hexamer. Zinc is also an important component of insulin secretion mechanisms and is likely to modulate the function of neighbouring cells via paracrine/autocrine interactions. Therefore beta cells undoubtedly need very efficient and specialized transporters to accumulate sufficient amounts of zinc in secretion vesicles. We report here the discovery and the characteristics of a new zinc transporter, ZnT-8, belonging to the CDF (Cation Diffusion Facilitator) family and expressed only in pancreatic beta cells. This transporter, localized in secretion vesicles membrane, facilitates the accumulation of zinc from the cytoplasm into intracellular insulin-containing vesicles and is a major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta cells. We discovered mammalian orthologs (rat, mouse, chimpanzee, and dog) and found these ZnT-8 proteins very similar (98% conserved amino acids) to human ZnT-8, indicating a high conservation during evolution. |
Mendeley readers
The data shown below were compiled from readership statistics for 101 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 2% |
| Japan | 1 | <1% |
| United Kingdom | 1 | <1% |
| France | 1 | <1% |
| Unknown | 96 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 24 | 24% |
| Researcher | 15 | 15% |
| Student > Bachelor | 9 | 9% |
| Student > Master | 8 | 8% |
| Professor | 6 | 6% |
| Other | 18 | 18% |
| Unknown | 21 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 29 | 29% |
| Biochemistry, Genetics and Molecular Biology | 21 | 21% |
| Medicine and Dentistry | 9 | 9% |
| Chemistry | 7 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 5% |
| Other | 8 | 8% |
| Unknown | 22 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 September 2017.
All research outputs
#4,696,232
of 22,787,797 outputs
Outputs from BioMetals
#79
of 642 outputs
Outputs of similar age
#10,400
of 57,250 outputs
Outputs of similar age from BioMetals
#2
of 10 outputs
Altmetric has tracked 22,787,797 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 642 research outputs from this source. They receive a mean Attention Score of 4.2. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 57,250 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 8 of them.