| Title |
Acinetobacter baumannii outer membrane protein a induces dendritic cell death through mitochondrial targeting
|
|---|---|
| Published in |
Journal of Microbiology, June 2010
|
| DOI | 10.1007/s12275-010-0155-1 |
| Pubmed ID | |
| Authors |
Jun Sik Lee, Chul Hee Choi, Jung Wook Kim, Je Chul Lee |
| Abstract |
Acinetobacter baumannii outer membrane protein A (AbOmpA) is a potential virulence factor that induces epithelial cell death, but its pathologic effects on the immune system have yet to be determined. The present study investigated the pathologic events occurring in dendritic cells (DCs) exposed to a cytotoxic concentration of AbOmpA. AbOmpA induced early-onset apoptosis and delayed-onset necrosis in DCs. AbOmpA targeted the mitochondria and induced the production of reactive oxygen species (ROS). ROS were directly responsible for both apoptosis and necrosis of AbOmpA-treated DCs. These results demonstrate that the AbOmpA secreted from A. baumannii induces DC death, which may impair T cell biology to induce adaptive immune responses against A. baumannii. |
Mendeley readers
The data shown below were compiled from readership statistics for 99 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| China | 1 | 1% |
| Unknown | 98 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 18 | 18% |
| Student > Master | 16 | 16% |
| Researcher | 13 | 13% |
| Student > Bachelor | 12 | 12% |
| Student > Doctoral Student | 6 | 6% |
| Other | 12 | 12% |
| Unknown | 22 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 23 | 23% |
| Biochemistry, Genetics and Molecular Biology | 21 | 21% |
| Agricultural and Biological Sciences | 14 | 14% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 6% |
| Medicine and Dentistry | 5 | 5% |
| Other | 9 | 9% |
| Unknown | 21 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 December 2022.
All research outputs
#5,049,987
of 23,975,976 outputs
Outputs from Journal of Microbiology
#88
of 842 outputs
Outputs of similar age
#20,395
of 96,784 outputs
Outputs of similar age from Journal of Microbiology
#1
of 3 outputs
Altmetric has tracked 23,975,976 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 842 research outputs from this source. They receive a mean Attention Score of 3.2. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 96,784 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them