| Title |
The PNPase, exosome and RNA helicases as the building components of evolutionarily-conserved RNA degradation machines
|
|---|---|
| Published in |
Journal of Biomedical Science, May 2007
|
| DOI | 10.1007/s11373-007-9178-y |
| Pubmed ID | |
| Authors |
Sue Lin-Chao, Ni-Ting Chiou, Gadi Schuster |
| Abstract |
The structure and function of polynucleotide phosphorylase (PNPase) and the exosome, as well as their associated RNA-helicases proteins, are described in the light of recent studies. The picture raised is of an evolutionarily conserved RNA-degradation machine which exonucleolytically degrades RNA from 3' to 5'. In prokaryotes and in eukaryotic organelles, a trimeric complex of PNPase forms a circular doughnut-shaped structure, in which the phosphorolysis catalytic sites are buried inside the barrel-shaped complex, while the RNA binding domains create a pore where RNA enters, reminiscent of the protein degrading complex, the proteasome. In some archaea and in the eukaryotes, several different proteins form a similar circle-shaped complex, the exosome, that is responsible for 3' to 5' exonucleolytic degradation of RNA as part of the processing, quality control, and general RNA degradation process. Both PNPase in prokaryotes and the exosome in eukaryotes are found in association with protein complexes that notably include RNA helicase. |
Mendeley readers
The data shown below were compiled from readership statistics for 70 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 1% |
| United States | 1 | 1% |
| Poland | 1 | 1% |
| France | 1 | 1% |
| Unknown | 66 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 17 | 24% |
| Researcher | 14 | 20% |
| Student > Bachelor | 6 | 9% |
| Professor > Associate Professor | 6 | 9% |
| Student > Postgraduate | 5 | 7% |
| Other | 10 | 14% |
| Unknown | 12 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 37 | 53% |
| Biochemistry, Genetics and Molecular Biology | 12 | 17% |
| Medicine and Dentistry | 3 | 4% |
| Social Sciences | 1 | 1% |
| Chemical Engineering | 1 | 1% |
| Other | 2 | 3% |
| Unknown | 14 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 February 2024.
All research outputs
#7,542,164
of 23,009,818 outputs
Outputs from Journal of Biomedical Science
#298
of 997 outputs
Outputs of similar age
#25,206
of 71,322 outputs
Outputs of similar age from Journal of Biomedical Science
#1
of 4 outputs
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