| Title |
The mammalian melastatin-related transient receptor potential cation channels: an overview
|
|---|---|
| Published in |
Pflügers Archiv - European Journal of Physiology, May 2005
|
| DOI | 10.1007/s00424-005-1428-0 |
| Pubmed ID | |
| Authors |
Robert Kraft, Christian Harteneck |
| Abstract |
The mammalian melastatin-related transient receptor potential (TRPM) subfamily contains eight members. TRPM proteins, consisting of six putative transmembrane domains and intracellular N and C termini, form monovalent-permeable cation channels with variable selectivity for Ca(2+), Mg(2+) and other divalent cations. Some functions are linked to their individual cation selectivity: the highly divalent-permeable cation channels TRPM6 and TRPM7 are involved in the control of Mg(2+) influx, whereas the Ca(2+)-impermeable channels TRPM4 and TRPM5 modulate cellular Ca(2+) entry by determining the membrane potential. TRPM2, TRPM3 and TRPM8 mediate a direct influx of Ca(2+) in response to specific stimuli. Electrophysiological properties of the founding member, melastatin (TRPM1), are unexplored. The individual TRPM members are activated by different stimuli, including voltage, Ca(2+), temperature, cell swelling, lipid compounds and other endogenous or exogenous ligands. This review summarizes molecular features, activation mechanisms, biophysical properties and modulators of TRPM channels. |
Mendeley readers
The data shown below were compiled from readership statistics for 120 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Chile | 2 | 2% |
| United States | 1 | <1% |
| Belgium | 1 | <1% |
| Unknown | 116 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 28 | 23% |
| Researcher | 22 | 18% |
| Student > Master | 17 | 14% |
| Student > Bachelor | 14 | 12% |
| Professor | 10 | 8% |
| Other | 18 | 15% |
| Unknown | 11 | 9% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 42 | 35% |
| Biochemistry, Genetics and Molecular Biology | 19 | 16% |
| Medicine and Dentistry | 15 | 13% |
| Neuroscience | 9 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 4% |
| Other | 14 | 12% |
| Unknown | 16 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 July 2021.
All research outputs
#7,856,604
of 23,818,521 outputs
Outputs from Pflügers Archiv - European Journal of Physiology
#476
of 1,973 outputs
Outputs of similar age
#21,029
of 59,430 outputs
Outputs of similar age from Pflügers Archiv - European Journal of Physiology
#9
of 16 outputs
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