| Title |
Serum CTX: A New Marker of Bone Resorption That Shows Treatment Effect More Often Than Other Markers Because of Low Coefficient of Variability and Large Changes with Bisphosphonate Therapy
|
|---|---|
| Published in |
Calcified Tissue International, February 2000
|
| DOI | 10.1007/pl00005830 |
| Pubmed ID | |
| Authors |
H. N. Rosen, A. C. Moses, J. Garber, I. D. Iloputaife, D. S. Ross, S. L. Lee, S. L. Greenspan |
| Abstract |
Serum CrossLaps is a new assay for measuring carboxy-terminal collagen crosslinks (CTX) in serum. This measurement is reported to be more specific to bone resorption than other measurements. However, the utility of this and other markers in monitoring patients on antiresorptive therapy depends on how often changes anticipated with therapy exceed changes attributable to random variability. In a study where subjects received either placebo or pamidronate, we calculated the minimum significant change (MSC), that is, the change that was sufficiently large that it was unlikely to be due to spontaneous variability. We also examined the changes in markers of bone turnover in subjects treated with pamidronate (APD) (30 mg i.v. in 500 ml D5W over 4 hours) to see how often observed changes in turnover after treatment exceeded the MSC. The MSC for serum CTX was 30.2%, and was significantly (P < 0.05) lower than the MSC for urinary NTX (54.0%), and not significantly different from the MSC of urinary DPD (20.6%). Ninety percent of subjects treated with APD had a decline in serum CTX that exceeded the MSC, compared with 74% for bone-specific alkaline phophatase (BSAP), 57% for urinary N-telopeptide cross-links (NTX), and 48% for free deoxypyridinoline. Changes in serum CTX correlated reasonably well with changes in spine BMD after 2 years (r = 0.47), but this correlation did not quite reach statistical significance because of the small number of subjects. In conclusion, the serum CTX assay shows greater utility for assessing efficacy of antiresorptive treatment than some previously described markers. |
Mendeley readers
The data shown below were compiled from readership statistics for 146 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Portugal | 1 | <1% |
| Denmark | 1 | <1% |
| Unknown | 143 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 27 | 18% |
| Student > Master | 21 | 14% |
| Researcher | 15 | 10% |
| Student > Bachelor | 13 | 9% |
| Other | 11 | 8% |
| Other | 32 | 22% |
| Unknown | 27 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 50 | 34% |
| Agricultural and Biological Sciences | 20 | 14% |
| Biochemistry, Genetics and Molecular Biology | 12 | 8% |
| Nursing and Health Professions | 9 | 6% |
| Sports and Recreations | 4 | 3% |
| Other | 15 | 10% |
| Unknown | 36 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 November 2023.
All research outputs
#5,476,946
of 25,480,126 outputs
Outputs from Calcified Tissue International
#329
of 1,887 outputs
Outputs of similar age
#11,280
of 111,685 outputs
Outputs of similar age from Calcified Tissue International
#5
of 16 outputs
Altmetric has tracked 25,480,126 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,887 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.2. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 111,685 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.