| Title |
Effect of TaiCatoxin (TCX) on the electrophysiological, mechanical and biochemical characteristics of spontaneously beating ventricular cardiomyocytes
|
|---|---|
| Published in |
Molecular and Cellular Biochemistry, March 1996
|
| DOI | 10.1007/bf00240032 |
| Pubmed ID | |
| Authors |
Elisabeth Fantini, Pierre Athias, Régine Tirosh, Arié Pinson, Fantini, Elisabeth, Athias, Pierre, Tirosh, Régine, Pinson, Arié |
| Abstract |
TaiCatoxin (TCX), a complex toxin isolated from Taipan snake venom, is believed to have a specific blocking activity on voltage-dependent cardiac calcium channels. The aim of this study was to investigate the effects of TCX on a broad range of heart muscle cell functions, i.e. electrophysiology, contractility, automaticity and the related biochemical modifications. Myocyte-enriched cultures were prepared from newborn rat heart ventricles. The transmembrane potentials were recorded with glass microelectrodes. The contractions were monitored photometrically. TCX decreased the action potential amplitudes, mainly by lowering the plateau. The action potential duration and the contraction parameters were decreased. Although TCX has a minor overall negative chronotropic effect, it evoked transient but severe arrhythmias and prolonged changes in the intercellular electrical coupling. Moreover, the action of TCX appeared to be dose-dependent. These effects are consistent with a specific blockade of the L-type, voltage-dependent calcium channels, but effects of other components of the toxin complex cannot be excluded. TCX also exhibits phospholipase A2 activity leading to the release of Iysophospholipids and FFA (acyl CoA and acyl carnitine), which have detrimental effects on cellular integrity and function. |
Mendeley readers
The data shown below were compiled from readership statistics for 6 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 1 | 17% |
| Unknown | 5 | 83% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 2 | 33% |
| Student > Bachelor | 1 | 17% |
| Other | 1 | 17% |
| Professor | 1 | 17% |
| Professor > Associate Professor | 1 | 17% |
| Other | 0 | 0% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 2 | 33% |
| Biochemistry, Genetics and Molecular Biology | 1 | 17% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 17% |
| Chemistry | 1 | 17% |
| Materials Science | 1 | 17% |
| Other | 0 | 0% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 November 2007.
All research outputs
#8,535,684
of 25,374,917 outputs
Outputs from Molecular and Cellular Biochemistry
#481
of 2,447 outputs
Outputs of similar age
#8,247
of 26,000 outputs
Outputs of similar age from Molecular and Cellular Biochemistry
#4
of 19 outputs
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