| Title |
Effects of Prolylendopeptidase Inhibitor Benzyloxycarbonyl-Methionyl-2(S)-Cyanopyrrolidine on Experimental Depressive Syndrome Development in Rats
|
|---|---|
| Published in |
Bulletin of Experimental Biology and Medicine, June 2009
|
| DOI | 10.1007/s10517-009-0458-6 |
| Pubmed ID | |
| Authors |
N. N. Khlebnikova, N. A. Krupina, N. G. Bogdanova, N. N. Zolotov, G. N. Kryzhanovskii |
| Abstract |
Model of experimental depressive syndrome in rats induced by repeated systemic injection of proneurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine showed that chronic injection of prolylendopeptidase inhibitor benzyloxycarbonyl-methionyl-2(S)-cyanopyrrolidine 30 min before pro-neurotoxin injection prevents the development of a number of depressive syndrome symptoms such as behavioral despair and biorhythmic disorders in forced swimming test, precludes the increase in anxiety-phobic level, prevents reduction of relative thymus mass. These results indicate that benzyloxycarbonyl-methionyl-2(S)-cyanopyrrolidine possesses antidepressant, anxiolytic, and/antistress properties. |
Mendeley readers
The data shown below were compiled from readership statistics for 7 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 7 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 2 | 29% |
| Researcher | 2 | 29% |
| Other | 1 | 14% |
| Student > Master | 1 | 14% |
| Lecturer > Senior Lecturer | 1 | 14% |
| Other | 0 | 0% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 2 | 29% |
| Psychology | 1 | 14% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 14% |
| Medicine and Dentistry | 1 | 14% |
| Chemistry | 1 | 14% |
| Other | 0 | 0% |
| Unknown | 1 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 February 2012.
All research outputs
#8,519,292
of 25,383,344 outputs
Outputs from Bulletin of Experimental Biology and Medicine
#194
of 1,415 outputs
Outputs of similar age
#42,877
of 124,729 outputs
Outputs of similar age from Bulletin of Experimental Biology and Medicine
#2
of 7 outputs
Altmetric has tracked 25,383,344 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,415 research outputs from this source. They receive a mean Attention Score of 2.5. This one has gotten more attention than average, scoring higher than 61% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 124,729 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than 5 of them.